Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry

[Image: see text] The enzyme (R)-3-hydroxybutyrate dehydrogenase (HBDH) catalyzes the enantioselective reduction of 3-oxocarboxylates to (R)-3-hydroxycarboxylates, the monomeric precursors of biodegradable polyesters. Despite its application in asymmetric reduction, which prompted several engineerin...

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Detalles Bibliográficos
Autores principales: Machado, Teresa F. G., Purg, Miha, McMahon, Stephen A., Read, Benjamin J., Oehler, Verena, Åqvist, Johan, Gloster, Tracey M., da Silva, Rafael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773212/
https://www.ncbi.nlm.nih.gov/pubmed/33391858
http://dx.doi.org/10.1021/acscatal.0c04736

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