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Correlation of C-arm CT acquired parenchymal blood volume (PBV) with (99m)Tc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up
OBJECTIVE: SPECT/CT with (99m)Tc-macroaggregated albumin (MAA) is generally used for diagnostic work-up prior to transarterial radioembolization (TARE) to exclude shunts and to provide additional information for treatment stratification and dose calculation. C-arm CT is used for determination of lob...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773241/ https://www.ncbi.nlm.nih.gov/pubmed/33378338 http://dx.doi.org/10.1371/journal.pone.0244235 |
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author | Weissinger, Matthias Vogel, Jonas Kupferschläger, Jürgen Dittmann, Helmut Castaneda Vega, Salvador Guillermo Grosse, Ulrich Artzner, Christoph Nikolaou, Konstantin la Fougere, Christian Grözinger, Gerd |
author_facet | Weissinger, Matthias Vogel, Jonas Kupferschläger, Jürgen Dittmann, Helmut Castaneda Vega, Salvador Guillermo Grosse, Ulrich Artzner, Christoph Nikolaou, Konstantin la Fougere, Christian Grözinger, Gerd |
author_sort | Weissinger, Matthias |
collection | PubMed |
description | OBJECTIVE: SPECT/CT with (99m)Tc-macroaggregated albumin (MAA) is generally used for diagnostic work-up prior to transarterial radioembolization (TARE) to exclude shunts and to provide additional information for treatment stratification and dose calculation. C-arm CT is used for determination of lobular vascular supply and assessment of parenchymal blood volume (PBV). Aim of this study was to correlate MAA-uptake and PBV-maps in hepatocellular carcinoma (HCC) and hepatic metastases of the colorectal carcinoma (CRC). MATERIALS AND METHODS: 34 patients underwent a PBV C-arm CT immediately followed by (99m)Tc-MAA injection and a SPECT/CT acquisition after 1 h uptake. MAA-uptake and PBV-maps were visually assessed and semi-quantitatively analyzed (MAA-tumor/liver-parenchyma = MAA-TBR or PBV in ml/100ml). In case of a poor match, tumors were additionally correlated with post-TARE (90)Y-Bremsstrahlung-SPECT/CT as a reference. RESULTS: 102 HCC or CRC metastases were analyzed. HCC presented with significantly higher MAA-TBR (7.6 vs. 3.9, p<0.05) compared to CRC. Tumors showed strong intra- and inter-individual dissimilarities between TBR and PBV with a weak correlations for capsular HCCs (r = 0.45, p<0.05) and no correlation for CRC. The demarcation of lesions was slightly better for both HCC and CRC in PBV-maps compared to MAA-SPECT/CT (exact match: 52%/50%; same intensity/homogeneity: 38%/39%; insufficient 10%/11%). MAA-SPECT/CT revealed a better visual correlation with post-therapeutic (90)Y-Bremsstrahlung-SPECT/CT. CONCLUSION: The acquisition of PBV can improve the detectability of small intrahepatic tumors and correlates with the MAA-Uptake in HCC. The results indicate that (99m)Tc-MAA-SPECT/CT remains to be the superior method for the prediction of post-therapeutic (90)Y-particle distribution, especially in CRC. However, intra-procedural PBV acquisition has the potential to become an additional factor for TARE planning, in addition to improving the determination of segment and tumor blood supply, which has been demonstrated previously. |
format | Online Article Text |
id | pubmed-7773241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77732412021-01-07 Correlation of C-arm CT acquired parenchymal blood volume (PBV) with (99m)Tc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up Weissinger, Matthias Vogel, Jonas Kupferschläger, Jürgen Dittmann, Helmut Castaneda Vega, Salvador Guillermo Grosse, Ulrich Artzner, Christoph Nikolaou, Konstantin la Fougere, Christian Grözinger, Gerd PLoS One Research Article OBJECTIVE: SPECT/CT with (99m)Tc-macroaggregated albumin (MAA) is generally used for diagnostic work-up prior to transarterial radioembolization (TARE) to exclude shunts and to provide additional information for treatment stratification and dose calculation. C-arm CT is used for determination of lobular vascular supply and assessment of parenchymal blood volume (PBV). Aim of this study was to correlate MAA-uptake and PBV-maps in hepatocellular carcinoma (HCC) and hepatic metastases of the colorectal carcinoma (CRC). MATERIALS AND METHODS: 34 patients underwent a PBV C-arm CT immediately followed by (99m)Tc-MAA injection and a SPECT/CT acquisition after 1 h uptake. MAA-uptake and PBV-maps were visually assessed and semi-quantitatively analyzed (MAA-tumor/liver-parenchyma = MAA-TBR or PBV in ml/100ml). In case of a poor match, tumors were additionally correlated with post-TARE (90)Y-Bremsstrahlung-SPECT/CT as a reference. RESULTS: 102 HCC or CRC metastases were analyzed. HCC presented with significantly higher MAA-TBR (7.6 vs. 3.9, p<0.05) compared to CRC. Tumors showed strong intra- and inter-individual dissimilarities between TBR and PBV with a weak correlations for capsular HCCs (r = 0.45, p<0.05) and no correlation for CRC. The demarcation of lesions was slightly better for both HCC and CRC in PBV-maps compared to MAA-SPECT/CT (exact match: 52%/50%; same intensity/homogeneity: 38%/39%; insufficient 10%/11%). MAA-SPECT/CT revealed a better visual correlation with post-therapeutic (90)Y-Bremsstrahlung-SPECT/CT. CONCLUSION: The acquisition of PBV can improve the detectability of small intrahepatic tumors and correlates with the MAA-Uptake in HCC. The results indicate that (99m)Tc-MAA-SPECT/CT remains to be the superior method for the prediction of post-therapeutic (90)Y-particle distribution, especially in CRC. However, intra-procedural PBV acquisition has the potential to become an additional factor for TARE planning, in addition to improving the determination of segment and tumor blood supply, which has been demonstrated previously. Public Library of Science 2020-12-30 /pmc/articles/PMC7773241/ /pubmed/33378338 http://dx.doi.org/10.1371/journal.pone.0244235 Text en © 2020 Weissinger et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Weissinger, Matthias Vogel, Jonas Kupferschläger, Jürgen Dittmann, Helmut Castaneda Vega, Salvador Guillermo Grosse, Ulrich Artzner, Christoph Nikolaou, Konstantin la Fougere, Christian Grözinger, Gerd Correlation of C-arm CT acquired parenchymal blood volume (PBV) with (99m)Tc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up |
title | Correlation of C-arm CT acquired parenchymal blood volume (PBV) with (99m)Tc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up |
title_full | Correlation of C-arm CT acquired parenchymal blood volume (PBV) with (99m)Tc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up |
title_fullStr | Correlation of C-arm CT acquired parenchymal blood volume (PBV) with (99m)Tc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up |
title_full_unstemmed | Correlation of C-arm CT acquired parenchymal blood volume (PBV) with (99m)Tc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up |
title_short | Correlation of C-arm CT acquired parenchymal blood volume (PBV) with (99m)Tc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up |
title_sort | correlation of c-arm ct acquired parenchymal blood volume (pbv) with (99m)tc-macroaggregated albumin (maa) spect/ct for radioembolization work-up |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773241/ https://www.ncbi.nlm.nih.gov/pubmed/33378338 http://dx.doi.org/10.1371/journal.pone.0244235 |
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