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Intrathecal catheter implantation decreases cerebrospinal fluid dynamics in cynomolgus monkeys
A detailed understanding of the CSF dynamics is needed for design and optimization of intrathecal drug delivery devices, drugs, and protocols. Preclinical research using large-animal models is important to help define drug pharmacokinetics-pharmacodynamics and safety. In this study, we investigated...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773283/ https://www.ncbi.nlm.nih.gov/pubmed/33378399 http://dx.doi.org/10.1371/journal.pone.0244090 |