Cargando…

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

Viruses are obligate intracellular parasites that make use of the host metabolic machineries to meet their biosynthetic needs. Thus, identifying the host pathways essential for the virus replication may lead to potential targets for therapeutic intervention. The mechanisms and pathways explored by S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dias, Suelen Silva Gomes, Soares, Vinicius Cardoso, Ferreira, André C., Sacramento, Carolina Q., Fintelman-Rodrigues, Natalia, Temerozo, Jairo R., Teixeira, Lívia, Nunes da Silva, Marcos Alexandre, Barreto, Ester, Mattos, Mayara, de Freitas, Caroline S., Azevedo-Quintanilha, Isaclaudia G., Manso, Pedro Paulo A., Miranda, Milene D., Siqueira, Marilda Mendonça, Hottz, Eugenio D., Pão, Camila R. R., Bou-Habib, Dumith C., Barreto-Vieira, Debora F., Bozza, Fernando A., Souza, Thiago M. L., Bozza, Patricia T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773323/ https://www.ncbi.nlm.nih.gov/pubmed/33326472 http://dx.doi.org/10.1371/journal.ppat.1009127

Ejemplares similares

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes
por: Ferreira, André C., et al.
Publicado: (2021)

Correction: SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes
por: Ferreira, André C., et al.
Publicado: (2021)

Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation
por: Soares, Vinicius Cardoso, et al.
Publicado: (2023)

HIV-1 and Its gp120 Inhibits the Influenza A(H1N1)pdm09 Life Cycle in an IFITM3-Dependent Fashion
por: Mesquita, Milene, et al.
Publicado: (2014)

Atazanavir, Alone or in Combination with Ritonavir, Inhibits SARS-CoV-2 Replication and Proinflammatory Cytokine Production
por: Fintelman-Rodrigues, Natalia, et al.
Publicado: (2020)

Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts
por: Teixeira, Lívia, et al.
Publicado: (2022)

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19
por: Hottz, Eugenio D., et al.
Publicado: (2020)

Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells
por: Sacramento, Carolina Q., et al.
Publicado: (2022)

The Chemokine CCL5 Inhibits the Replication of Influenza A Virus Through SAMHD1 Modulation
por: Silva, Thauane, et al.
Publicado: (2021)

Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology
por: Temerozo, Jairo R., et al.
Publicado: (2022)

Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
por: Hottz, Eugenio D., et al.
Publicado: (2022)

Severe influenza infection is associated with inflammatory programmed cell death in infected macrophages
por: Ferreira, André C., et al.
Publicado: (2023)

Metabolic reprogramming and lipid droplets are involved in Zika virus replication in neural cells
por: Dias, Suelen Silva Gomes, et al.
Publicado: (2023)

Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors than Isoflavone and Flavones
por: Chaves, Otávio Augusto, et al.
Publicado: (2022)

Increased platelet activation and platelet-inflammasome engagement during chikungunya infection
por: Gomes de Azevedo-Quintanilha, Isaclaudia, et al.
Publicado: (2022)

Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteases
por: Chaves, Otávio Augusto, et al.
Publicado: (2022)

Lipid droplets in Zika neuroinfection: Potential targets for intervention?
por: Dias, Suelen Silva Gomes, et al.
Publicado: (2023)

Macrophage Resistance to HIV-1 Infection Is Enhanced by the Neuropeptides VIP and PACAP
por: Temerozo, Jairo R., et al.
Publicado: (2013)

Proteomic Profile of Procoagulant Extracellular Vesicles Reflects Complement System Activation and Platelet Hyperreactivity of Patients with Severe COVID-19
por: Moraes, Emilly Caroline dos Santos, et al.
Publicado: (2022)

Platelets in Immune Response to Virus and Immunopathology of Viral Infections
por: Hottz, Eugenio D., et al.
Publicado: (2018)

Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR –PPARγ Signalling in Macrophages
por: Souza-Moreira, Luciana, et al.
Publicado: (2019)

Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19
por: Trugilho, Monique R. O., et al.
Publicado: (2022)

Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way
por: Chaves, Otávio Augusto, et al.
Publicado: (2022)

Platelet‐leukocyte interactions in COVID‐19: Contributions to hypercoagulability, inflammation, and disease severity
por: Hottz, Eugenio D., et al.
Publicado: (2022)

Lipid droplets: platforms with multiple functions in cancer hallmarks
por: Cruz, André L. S., et al.
Publicado: (2020)

Dengue induces iNOS expression and nitric oxide synthesis in platelets through IL-1R
por: Pinheiro, Mariana Brandi Mendonça, et al.
Publicado: (2022)

HIV-1 Tat protein enhances the intracellular growth of Leishmania amazonensis via the ds-RNA induced protein PKR
por: Vivarini, Áislan de Carvalho, et al.
Publicado: (2015)

Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
por: Hottz, Eugenio D., et al.
Publicado: (2015)

Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin
por: Temerozo, Jairo R., et al.
Publicado: (2023)

Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating
por: Salerno, José Alexandre, et al.
Publicado: (2021)

Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 M(pro), Impairing Variants Replication In Vitro and In Vivo
por: Chaves, Otávio Augusto, et al.
Publicado: (2021)

Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
por: Martins-Gonçalves, Remy, et al.
Publicado: (2023)

Neuroendocrine Control of Macrophage Development and Function
por: Jurberg, Arnon Dias, et al.
Publicado: (2018)

Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
por: Souza, Thiago Moreno Lopes e, et al.
Publicado: (2015)

Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation
por: Souza, Thiago Moreno L., et al.
Publicado: (2023)

Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
por: Fintelman-Rodrigues, Natalia, et al.
Publicado: (2021)

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics
por: Wang, Xuanting, et al.
Publicado: (2021)

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture
por: Wang, Xuanting, et al.
Publicado: (2022)

SARS-CoV-2: Ultrastructural Characterization of Morphogenesis in an In Vitro System
por: Barreto-Vieira, Debora Ferreira, et al.
Publicado: (2022)

SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites
por: Lechuga, Guilherme C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kjojspcas6bac5ihgsbganf9fp