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Transport mechanism of P4 ATPase phosphatidylcholine flippases

The P4 ATPases use ATP hydrolysis to transport large lipid substrates across lipid bilayers. The structures of the endosome- and Golgi-localized phosphatidylserine flippases—such as the yeast Drs2 and human ATP8A1—have recently been reported. However, a substrate-binding site on the cytosolic side h...

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Detalles Bibliográficos
Autores principales:	Bai, Lin, You, Qinglong, Jain, Bhawik K, Duan, H Diessel, Kovach, Amanda, Graham, Todd R, Li, Huilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773333/ https://www.ncbi.nlm.nih.gov/pubmed/33320091 http://dx.doi.org/10.7554/eLife.62163

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