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Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease
Vascular and kidney dysfunction commonly co-exist. There is a need for biomarkers of vascular health. Circulating microRNAs are biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats with nephrotoxic nephritis (NTN) and humans with acute endothelial and renal injur...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773582/ https://www.ncbi.nlm.nih.gov/pubmed/33392483 http://dx.doi.org/10.1016/j.isci.2020.101937 |
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author | Scullion, Kathleen M. Vliegenthart, A. D. Bastiaan Rivoli, Laura Oosthuyzen, Wilna Farrah, Tariq E. Czopek, Alicja Webb, David J. Hunter, Robert W. Bailey, Matthew A. Dhaun, Neeraj Dear, James W. |
author_facet | Scullion, Kathleen M. Vliegenthart, A. D. Bastiaan Rivoli, Laura Oosthuyzen, Wilna Farrah, Tariq E. Czopek, Alicja Webb, David J. Hunter, Robert W. Bailey, Matthew A. Dhaun, Neeraj Dear, James W. |
author_sort | Scullion, Kathleen M. |
collection | PubMed |
description | Vascular and kidney dysfunction commonly co-exist. There is a need for biomarkers of vascular health. Circulating microRNAs are biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats with nephrotoxic nephritis (NTN) and humans with acute endothelial and renal injury (vasculitis associated with autoantibodies to neutrophil cytoplasm antigens (ANCAs)). We compared these findings to those from patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) and explored the relationship between miR-126 and vascular dysfunction. In NTN, miR-126 was reduced. In ANCA vasculitis (N = 70), pre-treatment miR-126 was reduced compared to health (N = 60) (88-fold). miR-126 increased 3.4-fold post-treatment but remained lower than in health (∼26-fold). Argonaute 2-bound miR-126 increased with ANCA vasculitis treatment. miR-126 did not differ between CKD (N = 30) and health but its concentration correlated with endothelial dysfunction. miR-126 was reduced in ESRD (N = 15) (∼350 fold). miR-126 may be a marker of vascular inflammation and could aid decision-making. |
format | Online Article Text |
id | pubmed-7773582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-77735822020-12-31 Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease Scullion, Kathleen M. Vliegenthart, A. D. Bastiaan Rivoli, Laura Oosthuyzen, Wilna Farrah, Tariq E. Czopek, Alicja Webb, David J. Hunter, Robert W. Bailey, Matthew A. Dhaun, Neeraj Dear, James W. iScience Article Vascular and kidney dysfunction commonly co-exist. There is a need for biomarkers of vascular health. Circulating microRNAs are biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats with nephrotoxic nephritis (NTN) and humans with acute endothelial and renal injury (vasculitis associated with autoantibodies to neutrophil cytoplasm antigens (ANCAs)). We compared these findings to those from patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) and explored the relationship between miR-126 and vascular dysfunction. In NTN, miR-126 was reduced. In ANCA vasculitis (N = 70), pre-treatment miR-126 was reduced compared to health (N = 60) (88-fold). miR-126 increased 3.4-fold post-treatment but remained lower than in health (∼26-fold). Argonaute 2-bound miR-126 increased with ANCA vasculitis treatment. miR-126 did not differ between CKD (N = 30) and health but its concentration correlated with endothelial dysfunction. miR-126 was reduced in ESRD (N = 15) (∼350 fold). miR-126 may be a marker of vascular inflammation and could aid decision-making. Elsevier 2020-12-13 /pmc/articles/PMC7773582/ /pubmed/33392483 http://dx.doi.org/10.1016/j.isci.2020.101937 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Scullion, Kathleen M. Vliegenthart, A. D. Bastiaan Rivoli, Laura Oosthuyzen, Wilna Farrah, Tariq E. Czopek, Alicja Webb, David J. Hunter, Robert W. Bailey, Matthew A. Dhaun, Neeraj Dear, James W. Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease |
title | Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease |
title_full | Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease |
title_fullStr | Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease |
title_full_unstemmed | Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease |
title_short | Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease |
title_sort | circulating argonaute-bound microrna-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773582/ https://www.ncbi.nlm.nih.gov/pubmed/33392483 http://dx.doi.org/10.1016/j.isci.2020.101937 |
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