Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells

Intravenous infusion of mesenchymal stem cells (MSCs) has been reported to provide therapeutic efficacy via microvascular remodeling in a spontaneously hypertensive rat. In this study, we demonstrate that intravenous infusion of MSCs increased the survival rate in a spontaneously hypertensive (strok...

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Autores principales: Nakazaki, Masahito, Oka, Shinichi, Sasaki, Masanori, Kataoka-Sasaki, Yuko, Nagahama, Hiroshi, Hashi, Kazuo, Kocsis, Jeffery D., Honmou, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773587/
https://www.ncbi.nlm.nih.gov/pubmed/33392407
http://dx.doi.org/10.1016/j.heliyon.2020.e05833
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author Nakazaki, Masahito
Oka, Shinichi
Sasaki, Masanori
Kataoka-Sasaki, Yuko
Nagahama, Hiroshi
Hashi, Kazuo
Kocsis, Jeffery D.
Honmou, Osamu
author_facet Nakazaki, Masahito
Oka, Shinichi
Sasaki, Masanori
Kataoka-Sasaki, Yuko
Nagahama, Hiroshi
Hashi, Kazuo
Kocsis, Jeffery D.
Honmou, Osamu
author_sort Nakazaki, Masahito
collection PubMed
description Intravenous infusion of mesenchymal stem cells (MSCs) has been reported to provide therapeutic efficacy via microvascular remodeling in a spontaneously hypertensive rat. In this study, we demonstrate that intravenous infusion of MSCs increased the survival rate in a spontaneously hypertensive (stroke prone) rat model in which organs including kidney, brain, heart and liver are damaged during aging due to spontaneous hypertension. Gene expression analysis indicated that infused MSCs activates transforming growth factor-β1-smad3/forkhead box O1 signaling pathway. Renal dysfunction was recovered after MSC infusion. Collectively, intravenous infusion of MSC may extend lifespan in this model system.
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spelling pubmed-77735872020-12-31 Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells Nakazaki, Masahito Oka, Shinichi Sasaki, Masanori Kataoka-Sasaki, Yuko Nagahama, Hiroshi Hashi, Kazuo Kocsis, Jeffery D. Honmou, Osamu Heliyon Research Article Intravenous infusion of mesenchymal stem cells (MSCs) has been reported to provide therapeutic efficacy via microvascular remodeling in a spontaneously hypertensive rat. In this study, we demonstrate that intravenous infusion of MSCs increased the survival rate in a spontaneously hypertensive (stroke prone) rat model in which organs including kidney, brain, heart and liver are damaged during aging due to spontaneous hypertension. Gene expression analysis indicated that infused MSCs activates transforming growth factor-β1-smad3/forkhead box O1 signaling pathway. Renal dysfunction was recovered after MSC infusion. Collectively, intravenous infusion of MSC may extend lifespan in this model system. Elsevier 2020-12-25 /pmc/articles/PMC7773587/ /pubmed/33392407 http://dx.doi.org/10.1016/j.heliyon.2020.e05833 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Nakazaki, Masahito
Oka, Shinichi
Sasaki, Masanori
Kataoka-Sasaki, Yuko
Nagahama, Hiroshi
Hashi, Kazuo
Kocsis, Jeffery D.
Honmou, Osamu
Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
title Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
title_full Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
title_fullStr Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
title_full_unstemmed Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
title_short Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
title_sort prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773587/
https://www.ncbi.nlm.nih.gov/pubmed/33392407
http://dx.doi.org/10.1016/j.heliyon.2020.e05833
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