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Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function
Defects in protein quality control have been increasingly recognized as pathogenic factors in the development of heart failure, a persistent devastating disease lacking efficacious therapies. Ubiquitin and ubiquitin-like proteins, a family of post-translational modifying polypeptides, play important...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773599/ https://www.ncbi.nlm.nih.gov/pubmed/33391028 http://dx.doi.org/10.3389/fphys.2020.612927 |
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author | Li, Jie Zou, Jianqiu Littlejohn, Rodney Liu, Jinbao Su, Huabo |
author_facet | Li, Jie Zou, Jianqiu Littlejohn, Rodney Liu, Jinbao Su, Huabo |
author_sort | Li, Jie |
collection | PubMed |
description | Defects in protein quality control have been increasingly recognized as pathogenic factors in the development of heart failure, a persistent devastating disease lacking efficacious therapies. Ubiquitin and ubiquitin-like proteins, a family of post-translational modifying polypeptides, play important roles in controlling protein quality by maintaining the stability and functional diversity of the proteome. NEDD8 (neural precursor cell expressed, developmentally downregulated 8), a small ubiquitin-like protein, was discovered two decades ago but until recently the biological significance of NEDD8 modifications (neddylation) in the heart has not been appreciated. In this review, we summarize the current knowledge of the biology of neddylation, highlighting several mechanisms by which neddylation regulates the function of its downstream targets, and discuss the expanding roles for neddylation in cardiac physiology and disease, with an emphasis on cardiac protein quality control. Finally, we outline challenges linked to the study of neddylation in health and disease. |
format | Online Article Text |
id | pubmed-7773599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77735992021-01-01 Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function Li, Jie Zou, Jianqiu Littlejohn, Rodney Liu, Jinbao Su, Huabo Front Physiol Physiology Defects in protein quality control have been increasingly recognized as pathogenic factors in the development of heart failure, a persistent devastating disease lacking efficacious therapies. Ubiquitin and ubiquitin-like proteins, a family of post-translational modifying polypeptides, play important roles in controlling protein quality by maintaining the stability and functional diversity of the proteome. NEDD8 (neural precursor cell expressed, developmentally downregulated 8), a small ubiquitin-like protein, was discovered two decades ago but until recently the biological significance of NEDD8 modifications (neddylation) in the heart has not been appreciated. In this review, we summarize the current knowledge of the biology of neddylation, highlighting several mechanisms by which neddylation regulates the function of its downstream targets, and discuss the expanding roles for neddylation in cardiac physiology and disease, with an emphasis on cardiac protein quality control. Finally, we outline challenges linked to the study of neddylation in health and disease. Frontiers Media S.A. 2020-12-17 /pmc/articles/PMC7773599/ /pubmed/33391028 http://dx.doi.org/10.3389/fphys.2020.612927 Text en Copyright © 2020 Li, Zou, Littlejohn, Liu and Su. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Li, Jie Zou, Jianqiu Littlejohn, Rodney Liu, Jinbao Su, Huabo Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function |
title | Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function |
title_full | Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function |
title_fullStr | Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function |
title_full_unstemmed | Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function |
title_short | Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function |
title_sort | neddylation, an emerging mechanism regulating cardiac development and function |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773599/ https://www.ncbi.nlm.nih.gov/pubmed/33391028 http://dx.doi.org/10.3389/fphys.2020.612927 |
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