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Exploring the impact of intestinal ion transport on the gut microbiota
The gut microbiota and the host are intimately connected. The host physiology dictates the intestinal environment through regulation of pH, ion concentration, mucus production, etc., all of which exerts a selective pressure on the gut microbiota. Since different regions of the gastrointestinal tract...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773683/ https://www.ncbi.nlm.nih.gov/pubmed/33425246 http://dx.doi.org/10.1016/j.csbj.2020.12.008 |
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author | Engevik, Amy C. Engevik, Melinda A. |
author_facet | Engevik, Amy C. Engevik, Melinda A. |
author_sort | Engevik, Amy C. |
collection | PubMed |
description | The gut microbiota and the host are intimately connected. The host physiology dictates the intestinal environment through regulation of pH, ion concentration, mucus production, etc., all of which exerts a selective pressure on the gut microbiota. Since different regions of the gastrointestinal tract are characterized by their own physicochemical conditions, distinct microbial communities are present in these locations. While it is widely accepted that the intestinal microbiome influences the host (tight junctions, cytokine/immune responses, diarrhea, etc.), the reciprocal interaction of the host on the microbiome is under-explored. This review aims to address these gaps in knowledge by focusing on how the host intestinal ion transport influences the luminal environment and thereby modulates the gut microbiota composition. |
format | Online Article Text |
id | pubmed-7773683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-77736832021-01-08 Exploring the impact of intestinal ion transport on the gut microbiota Engevik, Amy C. Engevik, Melinda A. Comput Struct Biotechnol J Review Article The gut microbiota and the host are intimately connected. The host physiology dictates the intestinal environment through regulation of pH, ion concentration, mucus production, etc., all of which exerts a selective pressure on the gut microbiota. Since different regions of the gastrointestinal tract are characterized by their own physicochemical conditions, distinct microbial communities are present in these locations. While it is widely accepted that the intestinal microbiome influences the host (tight junctions, cytokine/immune responses, diarrhea, etc.), the reciprocal interaction of the host on the microbiome is under-explored. This review aims to address these gaps in knowledge by focusing on how the host intestinal ion transport influences the luminal environment and thereby modulates the gut microbiota composition. Research Network of Computational and Structural Biotechnology 2020-12-16 /pmc/articles/PMC7773683/ /pubmed/33425246 http://dx.doi.org/10.1016/j.csbj.2020.12.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Engevik, Amy C. Engevik, Melinda A. Exploring the impact of intestinal ion transport on the gut microbiota |
title | Exploring the impact of intestinal ion transport on the gut microbiota |
title_full | Exploring the impact of intestinal ion transport on the gut microbiota |
title_fullStr | Exploring the impact of intestinal ion transport on the gut microbiota |
title_full_unstemmed | Exploring the impact of intestinal ion transport on the gut microbiota |
title_short | Exploring the impact of intestinal ion transport on the gut microbiota |
title_sort | exploring the impact of intestinal ion transport on the gut microbiota |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773683/ https://www.ncbi.nlm.nih.gov/pubmed/33425246 http://dx.doi.org/10.1016/j.csbj.2020.12.008 |
work_keys_str_mv | AT engevikamyc exploringtheimpactofintestinaliontransportonthegutmicrobiota AT engevikmelindaa exploringtheimpactofintestinaliontransportonthegutmicrobiota |