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Exploring the impact of intestinal ion transport on the gut microbiota

The gut microbiota and the host are intimately connected. The host physiology dictates the intestinal environment through regulation of pH, ion concentration, mucus production, etc., all of which exerts a selective pressure on the gut microbiota. Since different regions of the gastrointestinal tract...

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Detalles Bibliográficos
Autores principales: Engevik, Amy C., Engevik, Melinda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773683/
https://www.ncbi.nlm.nih.gov/pubmed/33425246
http://dx.doi.org/10.1016/j.csbj.2020.12.008
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author Engevik, Amy C.
Engevik, Melinda A.
author_facet Engevik, Amy C.
Engevik, Melinda A.
author_sort Engevik, Amy C.
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description The gut microbiota and the host are intimately connected. The host physiology dictates the intestinal environment through regulation of pH, ion concentration, mucus production, etc., all of which exerts a selective pressure on the gut microbiota. Since different regions of the gastrointestinal tract are characterized by their own physicochemical conditions, distinct microbial communities are present in these locations. While it is widely accepted that the intestinal microbiome influences the host (tight junctions, cytokine/immune responses, diarrhea, etc.), the reciprocal interaction of the host on the microbiome is under-explored. This review aims to address these gaps in knowledge by focusing on how the host intestinal ion transport influences the luminal environment and thereby modulates the gut microbiota composition.
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spelling pubmed-77736832021-01-08 Exploring the impact of intestinal ion transport on the gut microbiota Engevik, Amy C. Engevik, Melinda A. Comput Struct Biotechnol J Review Article The gut microbiota and the host are intimately connected. The host physiology dictates the intestinal environment through regulation of pH, ion concentration, mucus production, etc., all of which exerts a selective pressure on the gut microbiota. Since different regions of the gastrointestinal tract are characterized by their own physicochemical conditions, distinct microbial communities are present in these locations. While it is widely accepted that the intestinal microbiome influences the host (tight junctions, cytokine/immune responses, diarrhea, etc.), the reciprocal interaction of the host on the microbiome is under-explored. This review aims to address these gaps in knowledge by focusing on how the host intestinal ion transport influences the luminal environment and thereby modulates the gut microbiota composition. Research Network of Computational and Structural Biotechnology 2020-12-16 /pmc/articles/PMC7773683/ /pubmed/33425246 http://dx.doi.org/10.1016/j.csbj.2020.12.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Engevik, Amy C.
Engevik, Melinda A.
Exploring the impact of intestinal ion transport on the gut microbiota
title Exploring the impact of intestinal ion transport on the gut microbiota
title_full Exploring the impact of intestinal ion transport on the gut microbiota
title_fullStr Exploring the impact of intestinal ion transport on the gut microbiota
title_full_unstemmed Exploring the impact of intestinal ion transport on the gut microbiota
title_short Exploring the impact of intestinal ion transport on the gut microbiota
title_sort exploring the impact of intestinal ion transport on the gut microbiota
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773683/
https://www.ncbi.nlm.nih.gov/pubmed/33425246
http://dx.doi.org/10.1016/j.csbj.2020.12.008
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