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Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies

The introduction of advanced therapy medicinal products (ATMPs) to the global pharma market has been revolutionizing the pharmaceutical industry and has opened new routes for treating various types of cancers and incurable diseases. In the past two decades, a noticeable part of clinical practices ha...

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Autores principales: Ramezankhani, Roya, Torabi, Shukoofeh, Minaei, Neda, Madani, Hoda, Rezaeiani, Siamak, Hassani, Seyedeh Nafiseh, Gee, Adrian P., Dominici, Massimo, Silva, Daniela Nascimento, Baharvand, Hossein, Hajizadeh-Saffar, Ensiyeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773756/
https://www.ncbi.nlm.nih.gov/pubmed/33392179
http://dx.doi.org/10.3389/fcell.2020.547653
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author Ramezankhani, Roya
Torabi, Shukoofeh
Minaei, Neda
Madani, Hoda
Rezaeiani, Siamak
Hassani, Seyedeh Nafiseh
Gee, Adrian P.
Dominici, Massimo
Silva, Daniela Nascimento
Baharvand, Hossein
Hajizadeh-Saffar, Ensiyeh
author_facet Ramezankhani, Roya
Torabi, Shukoofeh
Minaei, Neda
Madani, Hoda
Rezaeiani, Siamak
Hassani, Seyedeh Nafiseh
Gee, Adrian P.
Dominici, Massimo
Silva, Daniela Nascimento
Baharvand, Hossein
Hajizadeh-Saffar, Ensiyeh
author_sort Ramezankhani, Roya
collection PubMed
description The introduction of advanced therapy medicinal products (ATMPs) to the global pharma market has been revolutionizing the pharmaceutical industry and has opened new routes for treating various types of cancers and incurable diseases. In the past two decades, a noticeable part of clinical practices has been devoting progressively to these products. The first step to develop such an ATMP product is to be familiar with other approved products to obtain a general view about this industry trend. The present paper depicts an overall perspective of approved ATMPs in different countries, while reflecting the degree of their success in a clinical point of view and highlighting their main safety issues and also related market size as a whole. In this regard, published articles regarding safety, efficacy, and market size of approved ATMPs were reviewed using the search engines PubMed, Scopus, and Google Scholar. For some products which the related papers were not available, data on the relevant company website were referenced. In this descriptive study, we have introduced and classified approved cell, gene, and tissue engineering-based products by different regulatory agencies, along with their characteristics, manufacturer, indication, approval date, related regulatory agency, dosage, product description, price and published data about their safety and efficacy. In addition, to gain insights about the commercial situation of each product, we have gathered accessible sale reports and market size information that pertain to some of these products.
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spelling pubmed-77737562021-01-01 Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies Ramezankhani, Roya Torabi, Shukoofeh Minaei, Neda Madani, Hoda Rezaeiani, Siamak Hassani, Seyedeh Nafiseh Gee, Adrian P. Dominici, Massimo Silva, Daniela Nascimento Baharvand, Hossein Hajizadeh-Saffar, Ensiyeh Front Cell Dev Biol Cell and Developmental Biology The introduction of advanced therapy medicinal products (ATMPs) to the global pharma market has been revolutionizing the pharmaceutical industry and has opened new routes for treating various types of cancers and incurable diseases. In the past two decades, a noticeable part of clinical practices has been devoting progressively to these products. The first step to develop such an ATMP product is to be familiar with other approved products to obtain a general view about this industry trend. The present paper depicts an overall perspective of approved ATMPs in different countries, while reflecting the degree of their success in a clinical point of view and highlighting their main safety issues and also related market size as a whole. In this regard, published articles regarding safety, efficacy, and market size of approved ATMPs were reviewed using the search engines PubMed, Scopus, and Google Scholar. For some products which the related papers were not available, data on the relevant company website were referenced. In this descriptive study, we have introduced and classified approved cell, gene, and tissue engineering-based products by different regulatory agencies, along with their characteristics, manufacturer, indication, approval date, related regulatory agency, dosage, product description, price and published data about their safety and efficacy. In addition, to gain insights about the commercial situation of each product, we have gathered accessible sale reports and market size information that pertain to some of these products. Frontiers Media S.A. 2020-12-17 /pmc/articles/PMC7773756/ /pubmed/33392179 http://dx.doi.org/10.3389/fcell.2020.547653 Text en Copyright © 2020 Ramezankhani, Torabi, Minaei, Madani, Rezaeiani, Hassani, Gee, Dominici, Silva, Baharvand and Hajizadeh-Saffar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ramezankhani, Roya
Torabi, Shukoofeh
Minaei, Neda
Madani, Hoda
Rezaeiani, Siamak
Hassani, Seyedeh Nafiseh
Gee, Adrian P.
Dominici, Massimo
Silva, Daniela Nascimento
Baharvand, Hossein
Hajizadeh-Saffar, Ensiyeh
Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies
title Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies
title_full Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies
title_fullStr Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies
title_full_unstemmed Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies
title_short Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies
title_sort two decades of global progress in authorized advanced therapy medicinal products: an emerging revolution in therapeutic strategies
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773756/
https://www.ncbi.nlm.nih.gov/pubmed/33392179
http://dx.doi.org/10.3389/fcell.2020.547653
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