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The Role of Location-Context Binding in Nonspatial Visual Working Memory

Successful retrieval of an item from visual working memory (VWM) often requires an associated representation of the trial-unique context in which that item was presented. In experiment 1, fMRI of 16 male and female humans replicated a previous dissociation of the effects of manipulating memory load...

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Autores principales: Cai, Ying, Fulvio, Jacqueline M., Yu, Qing, Sheldon, Andrew D., Postle, Bradley R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773890/
https://www.ncbi.nlm.nih.gov/pubmed/33257529
http://dx.doi.org/10.1523/ENEURO.0430-20.2020
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author Cai, Ying
Fulvio, Jacqueline M.
Yu, Qing
Sheldon, Andrew D.
Postle, Bradley R.
author_facet Cai, Ying
Fulvio, Jacqueline M.
Yu, Qing
Sheldon, Andrew D.
Postle, Bradley R.
author_sort Cai, Ying
collection PubMed
description Successful retrieval of an item from visual working memory (VWM) often requires an associated representation of the trial-unique context in which that item was presented. In experiment 1, fMRI of 16 male and female humans replicated a previous dissociation of the effects of manipulating memory load in comparison to the effects of manipulating context binding, by comparing VWM for one oriented line versus for three lines individuated by their location versus for three “heterogeneous” items drawn from different categories (orientation, color, and luminance): delay-period fMRI signal in frontal cortex and intraparietal sulcus (IPS) was sensitive to stimulus homogeneity rather than to memory load per se. Additionally, inspection of behavioral performance revealed a broad range of individual differences in the probability of responses to nontargets (also known as “swap errors”), and a post hoc comparison of high swap-error versus low swap-error groups generated several intriguing results: at recall, high swap-error subjects were seen to represent both the orientation and the location of the probed item less strongly, and with less differentiation from nonprobed items, and delay-period signal in IPS predicted behavioral and neural correlates of context binding at recall. In experiment 2, which was a preregistered replication, the 27 male and female humans were grouped into low and high swap-error groups by median split, and the results were broadly consistent with experiment 1. These results present a neural correlate of swap errors, and suggest that delay-period activity of the IPS may be more important for the operation of context binding than for representation per se of stimulus identity.
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spelling pubmed-77738902020-12-31 The Role of Location-Context Binding in Nonspatial Visual Working Memory Cai, Ying Fulvio, Jacqueline M. Yu, Qing Sheldon, Andrew D. Postle, Bradley R. eNeuro Research Article: New Research Successful retrieval of an item from visual working memory (VWM) often requires an associated representation of the trial-unique context in which that item was presented. In experiment 1, fMRI of 16 male and female humans replicated a previous dissociation of the effects of manipulating memory load in comparison to the effects of manipulating context binding, by comparing VWM for one oriented line versus for three lines individuated by their location versus for three “heterogeneous” items drawn from different categories (orientation, color, and luminance): delay-period fMRI signal in frontal cortex and intraparietal sulcus (IPS) was sensitive to stimulus homogeneity rather than to memory load per se. Additionally, inspection of behavioral performance revealed a broad range of individual differences in the probability of responses to nontargets (also known as “swap errors”), and a post hoc comparison of high swap-error versus low swap-error groups generated several intriguing results: at recall, high swap-error subjects were seen to represent both the orientation and the location of the probed item less strongly, and with less differentiation from nonprobed items, and delay-period signal in IPS predicted behavioral and neural correlates of context binding at recall. In experiment 2, which was a preregistered replication, the 27 male and female humans were grouped into low and high swap-error groups by median split, and the results were broadly consistent with experiment 1. These results present a neural correlate of swap errors, and suggest that delay-period activity of the IPS may be more important for the operation of context binding than for representation per se of stimulus identity. Society for Neuroscience 2020-12-15 /pmc/articles/PMC7773890/ /pubmed/33257529 http://dx.doi.org/10.1523/ENEURO.0430-20.2020 Text en Copyright © 2020 Cai et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Cai, Ying
Fulvio, Jacqueline M.
Yu, Qing
Sheldon, Andrew D.
Postle, Bradley R.
The Role of Location-Context Binding in Nonspatial Visual Working Memory
title The Role of Location-Context Binding in Nonspatial Visual Working Memory
title_full The Role of Location-Context Binding in Nonspatial Visual Working Memory
title_fullStr The Role of Location-Context Binding in Nonspatial Visual Working Memory
title_full_unstemmed The Role of Location-Context Binding in Nonspatial Visual Working Memory
title_short The Role of Location-Context Binding in Nonspatial Visual Working Memory
title_sort role of location-context binding in nonspatial visual working memory
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773890/
https://www.ncbi.nlm.nih.gov/pubmed/33257529
http://dx.doi.org/10.1523/ENEURO.0430-20.2020
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