Generation of a Genetically Modified Chimeric Plasmodium falciparum Parasite Expressing Plasmodium vivax Circumsporozoite Protein for Malaria Vaccine Development

Chimeric rodent malaria parasites with the endogenous circumsporozoite protein (csp) gene replaced with csp from the human parasites Plasmodium falciparum (Pf) and P. vivax (Pv) are used in preclinical evaluation of CSP vaccines. Chimeric rodent parasites expressing PfCSP have also been assessed as...

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Detalles Bibliográficos
Autores principales: Miyazaki, Yukiko, Marin-Mogollon, Catherin, Imai, Takashi, Mendes, António M., van der Laak, Rianne, Sturm, Angelika, Geurten, Fiona J. A., Miyazaki, Shinya, Chevalley-Maurel, Severine, Ramesar, Jai, Kolli, Surendra K., Kroeze, Hans, van Schuijlenburg, Roos, Salman, Ahmed M., Wilder, Brandon K., Reyes-Sandoval, Arturo, Dechering, Koen J., Prudêncio, Miguel, Janse, Chris J., Khan, Shahid M., Franke-Fayard, Blandine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773900/
https://www.ncbi.nlm.nih.gov/pubmed/33392104
http://dx.doi.org/10.3389/fcimb.2020.591046

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