Cargando…

Directed Evolution of AAV Serotype 5 for Increased Hepatocyte Transduction and Retained Low Humoral Seroreactivity

Most recombinant adeno-associated virus (AAV) capsids utilized in liver gene therapy have significant levels of pre-existing neutralizing antibodies in the human population. These neutralizing factors limit the patient pools eligible for receiving AAV-mediated therapies. AAV serotype 5 (AAV5) does n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qian, Randolph, Xiao, Bin, Li, Juan, Xiao, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773954/ https://www.ncbi.nlm.nih.gov/pubmed/33426144 http://dx.doi.org/10.1016/j.omtm.2020.10.010

Ejemplares similares

Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity
por: Biswas, Moanaro, et al.
Publicado: (2020)

Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
por: Chakrabarty, Paramita, et al.
Publicado: (2013)

Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice
por: Zou, Chenhui, et al.
Publicado: (2020)

Preferred transduction with AAV8 and AAV9 via thalamic administration in the MPS IIIB model: A comparison of four rAAV serotypes
por: Gilkes, J.A., et al.
Publicado: (2015)

Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae
por: Omichi, Ryotaro, et al.
Publicado: (2020)

Computer-Aided Directed Evolution Generates Novel AAV Variants with High Transduction Efficiency
por: Han, Zengpeng, et al.
Publicado: (2023)

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors
por: Wang, Qizhao, et al.
Publicado: (2016)

Superior human hepatocyte transduction with Adeno-associated Virus Vector Serotype 7
por: Shao, Wenwei, et al.
Publicado: (2019)

Directed evolution of AAV accounting for long-term and enhanced transduction of cardiovascular endothelial cells in vivo
por: Liu, Y.B., et al.
Publicado: (2021)

Application of in-vitro-cultured primary hepatocytes to evaluate species translatability and AAV transduction mechanisms of action
por: Liu, Su, et al.
Publicado: (2022)

Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2
por: Cabanes-Creus, Marti, et al.
Publicado: (2020)

Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog
por: Shao, Wenwei, et al.
Publicado: (2022)

Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors
por: Ran, Gai, et al.
Publicado: (2020)

Development of optimized AAV3 serotype vectors: Mechanism of high-efficiency transduction of human liver cancer cells
por: Cheng, Binbin, et al.
Publicado: (2011)

Targeting Visceral Fat by Intraperitoneal Delivery of Novel AAV Serotype Vector Restricting Off-Target Transduction in Liver
por: Huang, Wei, et al.
Publicado: (2017)

Direct Interaction of Human Serum Proteins with AAV Virions to Enhance AAV Transduction: Immediate Impact on Clinical Applications
por: Wang, Mei, et al.
Publicado: (2016)

Humoral Immune Response to AAV
por: Calcedo, Roberto, et al.
Publicado: (2013)

Single amino acid insertion allows functional transduction of murine hepatocytes with human liver tropic AAV capsids
por: Cabanes-Creus, Marti, et al.
Publicado: (2021)

An AAV capsid increases transduction of striatum and a ChAT promoter allows selective cholinergic neuron transduction
por: Santoscoy, Miguel C., et al.
Publicado: (2023)

Increased seroreactivity to HERV-K10 peptides in patients with HTLV myelopathy
por: Perzova, Raisa, et al.
Publicado: (2013)

Increased seroreactivity to proinsulin and homologous mycobacterial peptides in latent autoimmune diabetes in adults
por: Niegowska, Magdalena, et al.
Publicado: (2017)

Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain
por: Aschauer, Dominik F., et al.
Publicado: (2013)

Peptide Ligands Incorporated into the Threefold Spike Capsid Domain to Re-Direct Gene Transduction of AAV8 and AAV9 In Vivo
por: Michelfelder, Stefan, et al.
Publicado: (2011)

Successful Transduction with AAV Vectors after Selective Depletion of Anti-AAV Antibodies by Immunoadsorption
por: Orlowski, Alejandro, et al.
Publicado: (2020)

Increased Seroreactivity to Glioma-Expressed Antigen 2 in Brain Tumor Patients under Radiation
por: Heisel, Sabrina M., et al.
Publicado: (2008)

Screened AAV variants permit efficient transduction access to supporting cells and hair cells
por: Hu, Xinde, et al.
Publicado: (2019)

AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction
por: Han, Zengpeng, et al.
Publicado: (2023)

AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes
por: Hui, Daniel J, et al.
Publicado: (2015)

First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers
por: Viitasalo, Liisa, et al.
Publicado: (2020)

Thermal Stability as a Determinant of AAV Serotype Identity
por: Bennett, Antonette, et al.
Publicado: (2017)

Various AAV Serotypes and Their Applications in Gene Therapy: An Overview
por: Issa, Shaza S., et al.
Publicado: (2023)

Reactive oxygen species enhance rAAV transduction by promoting its escape from late endosomes
por: Huang, Xiaoping, et al.
Publicado: (2023)

Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor
por: Pillay, Sirika, et al.
Publicado: (2017)

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys
por: Fuchs, Sebastian P., et al.
Publicado: (2019)

Seroreactivity to Dirofilaria antigens in people from different areas of Serbia
por: Tasić-Otašević, Suzana A, et al.
Publicado: (2014)

Seroreactivity to Q Fever Among Slaughterhouse Workers in South Korea
por: Chu, Hyuk, et al.
Publicado: (2017)

Seroreactivity against Marburg or related filoviruses in West and Central Africa
por: Steffen, Imke, et al.
Publicado: (2020)

AAV-mediated photoreceptor transduction of the pig cone-enriched retina
por: Mussolino, C, et al.
Publicado: (2011)

Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors
por: Moulay, Gilles, et al.
Publicado: (2010)

Role of Essential Metal Ions in AAV Vector-Mediated Transduction
por: Rambhai, Himanshu K., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l24140k12mao100c4vmqb80b41