Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease

Despite intuitive insights into differential proteolysis of amyloid precursor protein (APP), the stochasticity behind local product formation through amyloidogenic pathway at individual synapses remain unclear. Here, we show that the major components of amyloidogenic machinery namely, APP and secret...

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Detalles Bibliográficos
Autores principales: Kedia, Shekhar, Ramakrishna, Pratyush, Netrakanti, Pallavi Rao, Singh, Nivedita, Sisodia, Sangram S., Jose, Mini, Kumar, Sathish, Mahadevan, Anita, Ramanan, Narendrakumar, Nadkarni, Suhita, Nair, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773964/
https://www.ncbi.nlm.nih.gov/pubmed/33409475
http://dx.doi.org/10.1016/j.isci.2020.101924

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