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Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis

OBJECTIVE: To evaluate change in bone mineral density (BMD) during development of knee osteoarthritis (OA) in elderly Chinese community residents. Further, to monitor disease progression by recording speed of sound (SOS), one parameter of BMD provided by quantitative ultrasound measurement. METHODS:...

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Autores principales: Fang, Liang, Xia, Chenjie, Xu, Huihui, Ge, Qinwen, Shi, Zhenyu, Kong, Liya, Zhang, Peng, Xu, Rui, Zou, Zhen, Wang, Pinger, Jin, Hongting, Tong, Peijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773972/
https://www.ncbi.nlm.nih.gov/pubmed/33437621
http://dx.doi.org/10.1016/j.jot.2020.07.006
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author Fang, Liang
Xia, Chenjie
Xu, Huihui
Ge, Qinwen
Shi, Zhenyu
Kong, Liya
Zhang, Peng
Xu, Rui
Zou, Zhen
Wang, Pinger
Jin, Hongting
Tong, Peijian
author_facet Fang, Liang
Xia, Chenjie
Xu, Huihui
Ge, Qinwen
Shi, Zhenyu
Kong, Liya
Zhang, Peng
Xu, Rui
Zou, Zhen
Wang, Pinger
Jin, Hongting
Tong, Peijian
author_sort Fang, Liang
collection PubMed
description OBJECTIVE: To evaluate change in bone mineral density (BMD) during development of knee osteoarthritis (OA) in elderly Chinese community residents. Further, to monitor disease progression by recording speed of sound (SOS), one parameter of BMD provided by quantitative ultrasound measurement. METHODS: A total of 4173 community residents of the Chinese mainland were organized to complete questionnaires and relevant measurements, including anthropometry, radiology and quantitative ultrasound (QUS). SOS measurements of the distal radius were acquired using QUS measurements. The Kellgren-Lawrence (KL) grade of knee OA was evaluated by two experienced radiographers using X-rays. Finally, a general linear models analysis was performed to determine potential relationships. Further, the area under the receiver operating characteristic curve (ROC AUC) was applied to assess the distinction model. RESULTS: The SOS score in the OA group was significantly lower than that in the control group (p ​< ​0.001). However, after adjustment for age and body mass index (BMI), no significant difference was observed in the male population (p ​= ​0.841), while a significantly lower SOS score presented in knee OA participants in the female population (p ​= ​0.033). A turning point in SOS scores, from increasing to decreasing trends, occurred around KL grade 2; the SOS score gradually increased with progression in participants from KL grades 0 to 2, whereas the SOS score presented a significant decrease in participants with KL grades 3 and 4. The AUC for the model to distinguish OA progression was 0.891. CONCLUSION: There was a non-linear and stage-specific association between SOS score and knee OA, which presented a positive relationship in early stages, but a negative relationship in advanced stages. A decline of SOS score in knee OA patients in early stages should alert clinicians to the possibility of disease progression. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: In the present study, the relationship between OA and BMD had established by SOS. The results suggested that close monitoring of SOS in elderly Chinese communities residents with knee OA could alert disease progression involvement by an easily accessible method, and help early referral to orthopedist consultation for further examination and treatment.
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spelling pubmed-77739722021-01-11 Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis Fang, Liang Xia, Chenjie Xu, Huihui Ge, Qinwen Shi, Zhenyu Kong, Liya Zhang, Peng Xu, Rui Zou, Zhen Wang, Pinger Jin, Hongting Tong, Peijian J Orthop Translat Original Article OBJECTIVE: To evaluate change in bone mineral density (BMD) during development of knee osteoarthritis (OA) in elderly Chinese community residents. Further, to monitor disease progression by recording speed of sound (SOS), one parameter of BMD provided by quantitative ultrasound measurement. METHODS: A total of 4173 community residents of the Chinese mainland were organized to complete questionnaires and relevant measurements, including anthropometry, radiology and quantitative ultrasound (QUS). SOS measurements of the distal radius were acquired using QUS measurements. The Kellgren-Lawrence (KL) grade of knee OA was evaluated by two experienced radiographers using X-rays. Finally, a general linear models analysis was performed to determine potential relationships. Further, the area under the receiver operating characteristic curve (ROC AUC) was applied to assess the distinction model. RESULTS: The SOS score in the OA group was significantly lower than that in the control group (p ​< ​0.001). However, after adjustment for age and body mass index (BMI), no significant difference was observed in the male population (p ​= ​0.841), while a significantly lower SOS score presented in knee OA participants in the female population (p ​= ​0.033). A turning point in SOS scores, from increasing to decreasing trends, occurred around KL grade 2; the SOS score gradually increased with progression in participants from KL grades 0 to 2, whereas the SOS score presented a significant decrease in participants with KL grades 3 and 4. The AUC for the model to distinguish OA progression was 0.891. CONCLUSION: There was a non-linear and stage-specific association between SOS score and knee OA, which presented a positive relationship in early stages, but a negative relationship in advanced stages. A decline of SOS score in knee OA patients in early stages should alert clinicians to the possibility of disease progression. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: In the present study, the relationship between OA and BMD had established by SOS. The results suggested that close monitoring of SOS in elderly Chinese communities residents with knee OA could alert disease progression involvement by an easily accessible method, and help early referral to orthopedist consultation for further examination and treatment. Chinese Speaking Orthopaedic Society 2020-11-06 /pmc/articles/PMC7773972/ /pubmed/33437621 http://dx.doi.org/10.1016/j.jot.2020.07.006 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Fang, Liang
Xia, Chenjie
Xu, Huihui
Ge, Qinwen
Shi, Zhenyu
Kong, Liya
Zhang, Peng
Xu, Rui
Zou, Zhen
Wang, Pinger
Jin, Hongting
Tong, Peijian
Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis
title Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis
title_full Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis
title_fullStr Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis
title_full_unstemmed Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis
title_short Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis
title_sort defining disease progression in chinese mainland people: association between bone mineral density and knee osteoarthritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773972/
https://www.ncbi.nlm.nih.gov/pubmed/33437621
http://dx.doi.org/10.1016/j.jot.2020.07.006
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