Cargando…

The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets

Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism. The fungus Aspergillus fumigatus is a leading infectious cause of death in immunocompromised patients, but the specifi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shwab, E. Keats, Juvvadi, Praveen R., Waitt, Greg, Shaheen, Shareef, Allen, John, Soderblom, Erik J., Bobay, Benjamin G., Asfaw, Yohannes G., Moseley, M. Arthur, Steinbach, William J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773993/ https://www.ncbi.nlm.nih.gov/pubmed/33323509 http://dx.doi.org/10.1128/mBio.02880-20

Ejemplares similares

Protein Kinase A Regulates Autophagy-Associated Proteins Impacting Growth and Virulence of Aspergillus fumigatus
por: Shwab, E. Keats, et al.
Publicado: (2022)

A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus
por: Shwab, E. Keats, et al.
Publicado: (2017)

Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus
por: Vargas-Muñiz, José M., et al.
Publicado: (2016)

Phosphorylation of Calcineurin at a Novel Serine-Proline Rich Region Orchestrates Hyphal Growth and Virulence in Aspergillus fumigatus
por: Juvvadi, Praveen R., et al.
Publicado: (2013)

1614. Gwt1 Inhibitor, APX2104, Protects Against Invasive Aspergillosis in Neutropenic Mouse Model
por: Shaheen, Shareef, et al.
Publicado: (2020)

Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus
por: Juvvadi, Praveen R., et al.
Publicado: (2022)

Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus
por: Juvvadi, Praveen R., et al.
Publicado: (2015)

Editorial: Advances in Aspergillus fumigatus Pathobiology
por: Lamoth, Frédéric, et al.
Publicado: (2016)

Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus
por: Juvvadi, Praveen R., et al.
Publicado: (2015)

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus
por: Falloon, Katie, et al.
Publicado: (2015)

Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?
por: Juvvadi, Praveen R, et al.
Publicado: (2015)

Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin
por: Mattos, Eliciane Cevolani, et al.
Publicado: (2020)

The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance
por: Mattos, Eliciane Cevolani, et al.
Publicado: (2020)

Quantitative Label-Free Phosphoproteomics Strategy for Multifaceted Experimental Designs
por: Soderblom, Erik J., et al.
Publicado: (2011)

Iron – A Key Nexus in the Virulence of Aspergillus fumigatus
por: Haas, Hubertus
Publicado: (2012)

Urease of Aspergillus fumigatus Is Required for Survival in Macrophages and Virulence
por: Xiong, Zhenzhen, et al.
Publicado: (2023)

Special Issue “Aspergillus fumigatus: From Diagnosis to Therapy”
por: Steinbach, William J.
Publicado: (2016)

The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance
por: dos Reis, Thaila Fernanda, et al.
Publicado: (2017)

The Lysine Deacetylase RpdA Is Essential for Virulence in Aspergillus fumigatus
por: Bauer, Ingo, et al.
Publicado: (2019)

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity
por: Ries, Laure Nicolas Annick, et al.
Publicado: (2021)

The AGC Kinase YpkA Regulates Sphingolipids Biosynthesis and Physically Interacts With SakA MAP Kinase in Aspergillus fumigatus
por: Fabri, João Henrique Tadini Marilhano, et al.
Publicado: (2019)

Aspergillus fumigatus versus Genus Aspergillus: Conservation, Adaptive Evolution and Specific Virulence Genes
por: Gupta, Shishir K., et al.
Publicado: (2021)

Phosphoproteomic Approaches for Identifying Phosphatase and Kinase Substrates
por: DeMarco, Andrew G., et al.
Publicado: (2023)

Protein kinases associated with the yeast phosphoproteome
por: Brinkworth, Ross I, et al.
Publicado: (2006)

Variation of virulence of five Aspergillus fumigatus isolates in four different infection models
por: Keizer, E. M., et al.
Publicado: (2021)

Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus
por: Manfiolli, Adriana Oliveira, et al.
Publicado: (2019)

Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential for Aspergillus fumigatus Virulence
por: Schrettl, Markus, et al.
Publicado: (2004)

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence
por: Heinekamp, Thorsten, et al.
Publicado: (2013)

rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus
por: Myers, Ryan R., et al.
Publicado: (2017)

Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway
por: Stewart, James I. P., et al.
Publicado: (2020)

2599. Studying the Effects of Altering Histone Modification on Aspergillus fumigatus Virulence
por: Lee, Pam, et al.
Publicado: (2019)

Arginine Auxotrophy Affects Siderophore Biosynthesis and Attenuates Virulence of Aspergillus fumigatus
por: Dietl, Anna-Maria, et al.
Publicado: (2020)

Pseudomonas aeruginosa Virulence Factors Support Voriconazole Effects on Aspergillus fumigatus
por: Sass, Gabriele, et al.
Publicado: (2021)

Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to Aspergillus fumigatus Virulence
por: Perez-Cuesta, Uxue, et al.
Publicado: (2021)

Aspergillus fumigatus in Poultry
por: Arné, Pascal, et al.
Publicado: (2011)

(15)N, (13)C and (1)H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus
por: Gobeil, Sophie M. C., et al.
Publicado: (2019)

Development of Azole Resistance in Aspergillus fumigatus during Azole Therapy Associated with Change in Virulence
por: Arendrup, Maiken Cavling, et al.
Publicado: (2010)

Correction: Variation of virulence of five Aspergillus fumigatus isolates in four different infection models
por: Keizer, E. M., et al.
Publicado: (2021)

Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus
por: Altwasser, Robert, et al.
Publicado: (2015)

Mitogen activated protein kinases (MAPK) and protein phosphatases are involved in Aspergillus fumigatus adhesion and biofilm formation
por: Manfiolli, Adriana Oliveira, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_aslo8dvecsfj5r0fa5qlk9gvpl