Cargando…

Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?

Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “h...

Descripción completa

Detalles Bibliográficos
Autores principales: Vázquez-Boland, José A., Wagner, Martin, Scortti, Mariela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774001/
https://www.ncbi.nlm.nih.gov/pubmed/33323519
http://dx.doi.org/10.1128/mBio.03126-20
_version_ 1783630172244672512
author Vázquez-Boland, José A.
Wagner, Martin
Scortti, Mariela
author_facet Vázquez-Boland, José A.
Wagner, Martin
Scortti, Mariela
author_sort Vázquez-Boland, José A.
collection PubMed
description Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “hypervirulent” clones, no distinctive bacterial trait has been identified so far that could account for the differential pathogenicity of these strains. Here, we discuss some preliminary observations in experimentally infected mice suggesting that serovar 4b hypervirulent strains may have a hitherto unrecognized capacity for prolonged in vivo survival. We propose the hypothesis that protracted survivability in primary infection foci in liver and spleen—the first target organs after intestinal translocation—may cause L. monocytogenes serovar 4b hypervirulent clones to have a higher probability of secondary dissemination to brain and placenta.
format Online
Article
Text
id pubmed-7774001
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-77740012021-01-05 Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection? Vázquez-Boland, José A. Wagner, Martin Scortti, Mariela mBio Opinion/Hypothesis Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “hypervirulent” clones, no distinctive bacterial trait has been identified so far that could account for the differential pathogenicity of these strains. Here, we discuss some preliminary observations in experimentally infected mice suggesting that serovar 4b hypervirulent strains may have a hitherto unrecognized capacity for prolonged in vivo survival. We propose the hypothesis that protracted survivability in primary infection foci in liver and spleen—the first target organs after intestinal translocation—may cause L. monocytogenes serovar 4b hypervirulent clones to have a higher probability of secondary dissemination to brain and placenta. American Society for Microbiology 2020-12-15 /pmc/articles/PMC7774001/ /pubmed/33323519 http://dx.doi.org/10.1128/mBio.03126-20 Text en Copyright © 2020 Vázquez-Boland et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Opinion/Hypothesis
Vázquez-Boland, José A.
Wagner, Martin
Scortti, Mariela
Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_full Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_fullStr Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_full_unstemmed Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_short Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_sort why are some listeria monocytogenes genotypes more likely to cause invasive (brain, placental) infection?
topic Opinion/Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774001/
https://www.ncbi.nlm.nih.gov/pubmed/33323519
http://dx.doi.org/10.1128/mBio.03126-20
work_keys_str_mv AT vazquezbolandjosea whyaresomelisteriamonocytogenesgenotypesmorelikelytocauseinvasivebrainplacentalinfection
AT wagnermartin whyaresomelisteriamonocytogenesgenotypesmorelikelytocauseinvasivebrainplacentalinfection
AT scorttimariela whyaresomelisteriamonocytogenesgenotypesmorelikelytocauseinvasivebrainplacentalinfection