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Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “h...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774001/ https://www.ncbi.nlm.nih.gov/pubmed/33323519 http://dx.doi.org/10.1128/mBio.03126-20 |
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author | Vázquez-Boland, José A. Wagner, Martin Scortti, Mariela |
author_facet | Vázquez-Boland, José A. Wagner, Martin Scortti, Mariela |
author_sort | Vázquez-Boland, José A. |
collection | PubMed |
description | Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “hypervirulent” clones, no distinctive bacterial trait has been identified so far that could account for the differential pathogenicity of these strains. Here, we discuss some preliminary observations in experimentally infected mice suggesting that serovar 4b hypervirulent strains may have a hitherto unrecognized capacity for prolonged in vivo survival. We propose the hypothesis that protracted survivability in primary infection foci in liver and spleen—the first target organs after intestinal translocation—may cause L. monocytogenes serovar 4b hypervirulent clones to have a higher probability of secondary dissemination to brain and placenta. |
format | Online Article Text |
id | pubmed-7774001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-77740012021-01-05 Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection? Vázquez-Boland, José A. Wagner, Martin Scortti, Mariela mBio Opinion/Hypothesis Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “hypervirulent” clones, no distinctive bacterial trait has been identified so far that could account for the differential pathogenicity of these strains. Here, we discuss some preliminary observations in experimentally infected mice suggesting that serovar 4b hypervirulent strains may have a hitherto unrecognized capacity for prolonged in vivo survival. We propose the hypothesis that protracted survivability in primary infection foci in liver and spleen—the first target organs after intestinal translocation—may cause L. monocytogenes serovar 4b hypervirulent clones to have a higher probability of secondary dissemination to brain and placenta. American Society for Microbiology 2020-12-15 /pmc/articles/PMC7774001/ /pubmed/33323519 http://dx.doi.org/10.1128/mBio.03126-20 Text en Copyright © 2020 Vázquez-Boland et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Opinion/Hypothesis Vázquez-Boland, José A. Wagner, Martin Scortti, Mariela Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection? |
title | Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection? |
title_full | Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection? |
title_fullStr | Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection? |
title_full_unstemmed | Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection? |
title_short | Why Are Some Listeria monocytogenes Genotypes More Likely To Cause Invasive (Brain, Placental) Infection? |
title_sort | why are some listeria monocytogenes genotypes more likely to cause invasive (brain, placental) infection? |
topic | Opinion/Hypothesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774001/ https://www.ncbi.nlm.nih.gov/pubmed/33323519 http://dx.doi.org/10.1128/mBio.03126-20 |
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