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Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort

BACKGROUND: Our study aimed to compare the clinical outcomes of patients with and without diabetes admitted to hospital with COVID-19. METHODS: This retrospective multicentre cohort study comprised 24 tertiary medical centres in France, and included 2851 patients (675 with diabetes) hospitalized for...

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Autores principales: Sutter, Willy, Duceau, Baptiste, Vignac, Maxime, Bonnet, Guillaume, Carlier, Aurélie, Roussel, Ronan, Trimaille, Antonin, Pommier, Thibaut, Guilleminot, Pierre, Sagnard, Audrey, Pastier, Julie, Weizman, Orianne, Giordano, Gauthier, Cellier, Joffrey, Geneste, Laura, Panagides, Vassili, Marsou, Wassima, Deney, Antoine, Karsenty, Clément, Attou, Sabir, Delmotte, Thomas, Ribeyrolles, Sophie, Chemaly, Pascale, Gautier, Alexandre, Fauvel, Charles, Chaumont, Corentin, Mika, Delphine, Pezel, Théo, Cohen, Ariel, Potier, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774010/
https://www.ncbi.nlm.nih.gov/pubmed/33388386
http://dx.doi.org/10.1016/j.diabet.2020.101222
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author Sutter, Willy
Duceau, Baptiste
Vignac, Maxime
Bonnet, Guillaume
Carlier, Aurélie
Roussel, Ronan
Trimaille, Antonin
Pommier, Thibaut
Guilleminot, Pierre
Sagnard, Audrey
Pastier, Julie
Weizman, Orianne
Giordano, Gauthier
Cellier, Joffrey
Geneste, Laura
Panagides, Vassili
Marsou, Wassima
Deney, Antoine
Karsenty, Clément
Attou, Sabir
Delmotte, Thomas
Ribeyrolles, Sophie
Chemaly, Pascale
Gautier, Alexandre
Fauvel, Charles
Chaumont, Corentin
Mika, Delphine
Pezel, Théo
Cohen, Ariel
Potier, Louis
author_facet Sutter, Willy
Duceau, Baptiste
Vignac, Maxime
Bonnet, Guillaume
Carlier, Aurélie
Roussel, Ronan
Trimaille, Antonin
Pommier, Thibaut
Guilleminot, Pierre
Sagnard, Audrey
Pastier, Julie
Weizman, Orianne
Giordano, Gauthier
Cellier, Joffrey
Geneste, Laura
Panagides, Vassili
Marsou, Wassima
Deney, Antoine
Karsenty, Clément
Attou, Sabir
Delmotte, Thomas
Ribeyrolles, Sophie
Chemaly, Pascale
Gautier, Alexandre
Fauvel, Charles
Chaumont, Corentin
Mika, Delphine
Pezel, Théo
Cohen, Ariel
Potier, Louis
author_sort Sutter, Willy
collection PubMed
description BACKGROUND: Our study aimed to compare the clinical outcomes of patients with and without diabetes admitted to hospital with COVID-19. METHODS: This retrospective multicentre cohort study comprised 24 tertiary medical centres in France, and included 2851 patients (675 with diabetes) hospitalized for COVID-19 between 26 February and 20 April 2020. A propensity score-matching (PSM) method (1:1 matching including patients’ characteristics, medical history, vital statistics and laboratory results) was used to compare patients with and without diabetes (n = 603 per group). The primary outcome was admission to an intensive care unit (ICU) and/or in-hospital death. RESULTS: After PSM, all baseline characteristics were well balanced between those with and without diabetes: mean age was 71.2 years; 61.8% were male; and mean BMI was 29 kg/m(2). A history of cardiovascular, chronic kidney and chronic obstructive pulmonary diseases were found in 32.8%, 22.1% and 6.4% of participants, respectively. The risk of experiencing the primary outcome was similar in patients with or without diabetes [hazard ratio (HR): 1.16, 95% confidence interval (CI): 0.95–1.41; P = 0.14], and was 1.29 (95% CI: 0.97–1.69) for in-hospital death, 1.26 (95% CI: 0.9–1.72) for death with no transfer to an ICU and 1.14 (95% CI: 0.88–1.47) with transfer to an ICU. CONCLUSION: In this retrospective study cohort of patients hospitalized for COVID-19, diabetes was not significantly associated with a higher risk of severe outcomes after PSM. TRIAL REGISTRATION NUMBER: NCT04344327.
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spelling pubmed-77740102020-12-31 Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort Sutter, Willy Duceau, Baptiste Vignac, Maxime Bonnet, Guillaume Carlier, Aurélie Roussel, Ronan Trimaille, Antonin Pommier, Thibaut Guilleminot, Pierre Sagnard, Audrey Pastier, Julie Weizman, Orianne Giordano, Gauthier Cellier, Joffrey Geneste, Laura Panagides, Vassili Marsou, Wassima Deney, Antoine Karsenty, Clément Attou, Sabir Delmotte, Thomas Ribeyrolles, Sophie Chemaly, Pascale Gautier, Alexandre Fauvel, Charles Chaumont, Corentin Mika, Delphine Pezel, Théo Cohen, Ariel Potier, Louis Diabetes Metab Original Article BACKGROUND: Our study aimed to compare the clinical outcomes of patients with and without diabetes admitted to hospital with COVID-19. METHODS: This retrospective multicentre cohort study comprised 24 tertiary medical centres in France, and included 2851 patients (675 with diabetes) hospitalized for COVID-19 between 26 February and 20 April 2020. A propensity score-matching (PSM) method (1:1 matching including patients’ characteristics, medical history, vital statistics and laboratory results) was used to compare patients with and without diabetes (n = 603 per group). The primary outcome was admission to an intensive care unit (ICU) and/or in-hospital death. RESULTS: After PSM, all baseline characteristics were well balanced between those with and without diabetes: mean age was 71.2 years; 61.8% were male; and mean BMI was 29 kg/m(2). A history of cardiovascular, chronic kidney and chronic obstructive pulmonary diseases were found in 32.8%, 22.1% and 6.4% of participants, respectively. The risk of experiencing the primary outcome was similar in patients with or without diabetes [hazard ratio (HR): 1.16, 95% confidence interval (CI): 0.95–1.41; P = 0.14], and was 1.29 (95% CI: 0.97–1.69) for in-hospital death, 1.26 (95% CI: 0.9–1.72) for death with no transfer to an ICU and 1.14 (95% CI: 0.88–1.47) with transfer to an ICU. CONCLUSION: In this retrospective study cohort of patients hospitalized for COVID-19, diabetes was not significantly associated with a higher risk of severe outcomes after PSM. TRIAL REGISTRATION NUMBER: NCT04344327. Published by Elsevier Masson SAS. 2021-07 2020-12-31 /pmc/articles/PMC7774010/ /pubmed/33388386 http://dx.doi.org/10.1016/j.diabet.2020.101222 Text en © 2020 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Sutter, Willy
Duceau, Baptiste
Vignac, Maxime
Bonnet, Guillaume
Carlier, Aurélie
Roussel, Ronan
Trimaille, Antonin
Pommier, Thibaut
Guilleminot, Pierre
Sagnard, Audrey
Pastier, Julie
Weizman, Orianne
Giordano, Gauthier
Cellier, Joffrey
Geneste, Laura
Panagides, Vassili
Marsou, Wassima
Deney, Antoine
Karsenty, Clément
Attou, Sabir
Delmotte, Thomas
Ribeyrolles, Sophie
Chemaly, Pascale
Gautier, Alexandre
Fauvel, Charles
Chaumont, Corentin
Mika, Delphine
Pezel, Théo
Cohen, Ariel
Potier, Louis
Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort
title Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort
title_full Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort
title_fullStr Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort
title_full_unstemmed Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort
title_short Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort
title_sort association of diabetes and outcomes in patients with covid-19: propensity score-matched analyses from a french retrospective cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774010/
https://www.ncbi.nlm.nih.gov/pubmed/33388386
http://dx.doi.org/10.1016/j.diabet.2020.101222
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