Immunosubunit β5i Knockout Suppresses Neovascularization and Restores Autophagy in Retinal Neovascularization by Targeting ATG5 for Degradation

PURPOSE: To investigate the functional role of immunoproteasome subunit β5i in pathologic retinal neovascularization (RNV) and its ability to link the immunoproteasome and autophagy. METHODS: Oxygen-induced retinopathy (OIR) was induced in wild-type (WT) and β5i knockout (KO) mouse pups on a C57BL/6...

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Detalles Bibliográficos
Autores principales: Ji, Liyang, Li, Li, Zhao, Ying, Liu, Shengqiang, Li, Jingmin, Zhang, Jinsong, Zhao, Qi, Wang, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774061/
https://www.ncbi.nlm.nih.gov/pubmed/33369639
http://dx.doi.org/10.1167/iovs.61.14.30

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