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Aspergillosis Complicating Severe Coronavirus Disease

Aspergillosis complicating severe influenza infection has been increasingly detected worldwide. Recently, coronavirus disease–associated pulmonary aspergillosis (CAPA) has been detected through rapid reports, primarily from centers in Europe. We provide a case series of CAPA, adding 20 cases to the...

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Autores principales: Marr, Kieren A., Platt, Andrew, Tornheim, Jeffrey A., Zhang, Sean X., Datta, Kausik, Cardozo, Celia, Garcia-Vidal, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774554/
https://www.ncbi.nlm.nih.gov/pubmed/33084566
http://dx.doi.org/10.3201/eid2701.202896
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author Marr, Kieren A.
Platt, Andrew
Tornheim, Jeffrey A.
Zhang, Sean X.
Datta, Kausik
Cardozo, Celia
Garcia-Vidal, Carolina
author_facet Marr, Kieren A.
Platt, Andrew
Tornheim, Jeffrey A.
Zhang, Sean X.
Datta, Kausik
Cardozo, Celia
Garcia-Vidal, Carolina
author_sort Marr, Kieren A.
collection PubMed
description Aspergillosis complicating severe influenza infection has been increasingly detected worldwide. Recently, coronavirus disease–associated pulmonary aspergillosis (CAPA) has been detected through rapid reports, primarily from centers in Europe. We provide a case series of CAPA, adding 20 cases to the literature, with review of pathophysiology, diagnosis, and outcomes. The syndromes of pulmonary aspergillosis complicating severe viral infections are distinct from classic invasive aspergillosis, which is recognized most frequently in persons with neutropenia and in other immunocompromised persons. Combined with severe viral infection, aspergillosis comprises a constellation of airway-invasive and angio-invasive disease and results in risks associated with poor airway fungus clearance and killing, including virus- or inflammation-associated epithelial damage, systemic immunosuppression, and underlying lung disease. Radiologic abnormalities can vary, reflecting different pathologies. Prospective studies reporting poor outcomes in CAPA patients underscore the urgent need for strategies to improve diagnosis, prevention, and therapy.
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spelling pubmed-77745542021-01-01 Aspergillosis Complicating Severe Coronavirus Disease Marr, Kieren A. Platt, Andrew Tornheim, Jeffrey A. Zhang, Sean X. Datta, Kausik Cardozo, Celia Garcia-Vidal, Carolina Emerg Infect Dis Synopsis Aspergillosis complicating severe influenza infection has been increasingly detected worldwide. Recently, coronavirus disease–associated pulmonary aspergillosis (CAPA) has been detected through rapid reports, primarily from centers in Europe. We provide a case series of CAPA, adding 20 cases to the literature, with review of pathophysiology, diagnosis, and outcomes. The syndromes of pulmonary aspergillosis complicating severe viral infections are distinct from classic invasive aspergillosis, which is recognized most frequently in persons with neutropenia and in other immunocompromised persons. Combined with severe viral infection, aspergillosis comprises a constellation of airway-invasive and angio-invasive disease and results in risks associated with poor airway fungus clearance and killing, including virus- or inflammation-associated epithelial damage, systemic immunosuppression, and underlying lung disease. Radiologic abnormalities can vary, reflecting different pathologies. Prospective studies reporting poor outcomes in CAPA patients underscore the urgent need for strategies to improve diagnosis, prevention, and therapy. Centers for Disease Control and Prevention 2021-01 /pmc/articles/PMC7774554/ /pubmed/33084566 http://dx.doi.org/10.3201/eid2701.202896 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Marr, Kieren A.
Platt, Andrew
Tornheim, Jeffrey A.
Zhang, Sean X.
Datta, Kausik
Cardozo, Celia
Garcia-Vidal, Carolina
Aspergillosis Complicating Severe Coronavirus Disease
title Aspergillosis Complicating Severe Coronavirus Disease
title_full Aspergillosis Complicating Severe Coronavirus Disease
title_fullStr Aspergillosis Complicating Severe Coronavirus Disease
title_full_unstemmed Aspergillosis Complicating Severe Coronavirus Disease
title_short Aspergillosis Complicating Severe Coronavirus Disease
title_sort aspergillosis complicating severe coronavirus disease
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774554/
https://www.ncbi.nlm.nih.gov/pubmed/33084566
http://dx.doi.org/10.3201/eid2701.202896
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