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Nuclear receptor LXRβ controls fitness and functionality of activated T cells

T cells increase cholesterol biosynthesis upon activation to generate substrates for cellular growth and proliferation. The ubiquitously expressed liver X receptor β (LXRβ) encoded by the Nr1h2 gene is a critical regulator of cholesterol homeostasis in mammalian cells; however, its cell-intrinsic ro...

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Detalles Bibliográficos
Autores principales:	Michaels, Anthony J., Campbell, Clarissa, Bou-Puerto, Regina, Rudensky, Alexander Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774588/ https://www.ncbi.nlm.nih.gov/pubmed/33373442 http://dx.doi.org/10.1084/jem.20201311

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