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Dihydropyrimidine dehydrogenase deficiency in patients with severe toxicity after 5-fluorouracil: a retrospective single-center study

BACKGROUND: 5-Fluorouracil (5-FU) is an agent frequently used in the treatment of solid cancers. A deficiency in the enzyme that catabolizes 5-FU leads to severe toxicity. The gene responsible for this enzyme is DPYD, located on chromosome 1q22. The most prevalent alteration described is DPYD*2A, wh...

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Detalles Bibliográficos
Autores principales:	Detailleur, Stephanie, Segelov, Eva, Re, Marzia Del, Prenen, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hellenic Society of Gastroenterology 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774667/ https://www.ncbi.nlm.nih.gov/pubmed/33414624 http://dx.doi.org/10.20524/aog.2020.0551

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