Disrupting polycystin-2 EF hand Ca(2+) affinity does not alter channel function or contribute to polycystic kidney disease

Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2. PKD2 encodes polycystin-2, which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells. Elevated internal Ca(2+) modulates polycystin-2 vol...

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Detalles Bibliográficos
Autores principales: Vien, Thuy N., Ng, Leo C. T., Smith, Jessica M., Dong, Ke, Krappitz, Matteus, Gainullin, Vladimir G., Fedeles, Sorin, Harris, Peter C., Somlo, Stefan, DeCaen, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774883/
https://www.ncbi.nlm.nih.gov/pubmed/33199522
http://dx.doi.org/10.1242/jcs.255562

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