A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar—A comprehensive investigation on factors of toxicity

Litchi fruits are a nutritious and commercial crop in the Indian state of Bihar. Litchi fruit contains a toxin, methylene cyclopropyl-glycine (MCPG), which is known to be fatal by causing encephalitis-related deaths. This is especially harmful when consumed by malnourished children. The first case o...

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Autores principales: Sinha, Sukesh Narayan, Ramakrishna, Ungarala Venkat, Sinha, P. K., Thakur, C. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774918/
https://www.ncbi.nlm.nih.gov/pubmed/33382820
http://dx.doi.org/10.1371/journal.pone.0244798
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author Sinha, Sukesh Narayan
Ramakrishna, Ungarala Venkat
Sinha, P. K.
Thakur, C. P.
author_facet Sinha, Sukesh Narayan
Ramakrishna, Ungarala Venkat
Sinha, P. K.
Thakur, C. P.
author_sort Sinha, Sukesh Narayan
collection PubMed
description Litchi fruits are a nutritious and commercial crop in the Indian state of Bihar. Litchi fruit contains a toxin, methylene cyclopropyl-glycine (MCPG), which is known to be fatal by causing encephalitis-related deaths. This is especially harmful when consumed by malnourished children. The first case of litchi toxicity was reported in Bihar in 2011. A similar event was recorded in 2014 among children admitted to the Muzaffarpur government hospital, Bihar. Litchi samples sent to ICMR-NIN were analyzed and MCPG was found to be present in both the pulp and seed of the fruit. Diethyl phosphate (DEP) metabolites were found in the urine samples of children who had consumed litchi fruit from this area indicating exposure to pesticide. The presence of both MCPG in litchi and DEP metabolites in urine samples highlights the need to conduct a comprehensive investigation that examines all factors of toxicity.
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spelling pubmed-77749182021-01-11 A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar—A comprehensive investigation on factors of toxicity Sinha, Sukesh Narayan Ramakrishna, Ungarala Venkat Sinha, P. K. Thakur, C. P. PLoS One Research Article Litchi fruits are a nutritious and commercial crop in the Indian state of Bihar. Litchi fruit contains a toxin, methylene cyclopropyl-glycine (MCPG), which is known to be fatal by causing encephalitis-related deaths. This is especially harmful when consumed by malnourished children. The first case of litchi toxicity was reported in Bihar in 2011. A similar event was recorded in 2014 among children admitted to the Muzaffarpur government hospital, Bihar. Litchi samples sent to ICMR-NIN were analyzed and MCPG was found to be present in both the pulp and seed of the fruit. Diethyl phosphate (DEP) metabolites were found in the urine samples of children who had consumed litchi fruit from this area indicating exposure to pesticide. The presence of both MCPG in litchi and DEP metabolites in urine samples highlights the need to conduct a comprehensive investigation that examines all factors of toxicity. Public Library of Science 2020-12-31 /pmc/articles/PMC7774918/ /pubmed/33382820 http://dx.doi.org/10.1371/journal.pone.0244798 Text en © 2020 Sinha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sinha, Sukesh Narayan
Ramakrishna, Ungarala Venkat
Sinha, P. K.
Thakur, C. P.
A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar—A comprehensive investigation on factors of toxicity
title A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar—A comprehensive investigation on factors of toxicity
title_full A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar—A comprehensive investigation on factors of toxicity
title_fullStr A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar—A comprehensive investigation on factors of toxicity
title_full_unstemmed A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar—A comprehensive investigation on factors of toxicity
title_short A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar—A comprehensive investigation on factors of toxicity
title_sort recurring disease outbreak following litchi fruit consumption among children in muzaffarpur, bihar—a comprehensive investigation on factors of toxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774918/
https://www.ncbi.nlm.nih.gov/pubmed/33382820
http://dx.doi.org/10.1371/journal.pone.0244798
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