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Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer
BACKGROUND: There are no epidemiologic data on the relation of depression before colorectal cancer diagnosis to colorectal cancer mortality among women with colorectal cancer, especially those who are postmenopausal. Our aim was to fill this research gap. METHODS: We analyzed data from a large prosp...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774930/ https://www.ncbi.nlm.nih.gov/pubmed/33382778 http://dx.doi.org/10.1371/journal.pone.0244728 |
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author | Liang, Xiaoyun Hendryx, Michael Qi, Lihong Lane, Dorothy Luo, Juhua |
author_facet | Liang, Xiaoyun Hendryx, Michael Qi, Lihong Lane, Dorothy Luo, Juhua |
author_sort | Liang, Xiaoyun |
collection | PubMed |
description | BACKGROUND: There are no epidemiologic data on the relation of depression before colorectal cancer diagnosis to colorectal cancer mortality among women with colorectal cancer, especially those who are postmenopausal. Our aim was to fill this research gap. METHODS: We analyzed data from a large prospective cohort in the US, the Women’s Health Initiative (WHI). The study included 2,396 women with incident colorectal cancer, assessed for depressive symptoms and antidepressant use before cancer diagnosis at baseline (screening visit in the WHI study) during 1993–1998. Participants were followed up from cancer diagnosis till 2018. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HRs) between depression (depressive symptoms or antidepressant use) at baseline, and all-cause mortality and colorectal cancer-specific mortality. RESULTS: Among women with colorectal cancer, there was no association between baseline depression and all-cause mortality or colorectal cancer-specific mortality after adjusting for age or multiple covariates. CONCLUSION: Among women with colorectal cancer, there was no statistically significant association between depression before colorectal cancer diagnosis and all-cause mortality or colorectal cancer-specific mortality. Further studies are warranted to assess depressive symptoms and antidepressant use, measured at multiple points from baseline to diagnosis, and their interactions with specific types of colorectal cancer treatment on the risk of death from colorectal cancer. |
format | Online Article Text |
id | pubmed-7774930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77749302021-01-11 Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer Liang, Xiaoyun Hendryx, Michael Qi, Lihong Lane, Dorothy Luo, Juhua PLoS One Research Article BACKGROUND: There are no epidemiologic data on the relation of depression before colorectal cancer diagnosis to colorectal cancer mortality among women with colorectal cancer, especially those who are postmenopausal. Our aim was to fill this research gap. METHODS: We analyzed data from a large prospective cohort in the US, the Women’s Health Initiative (WHI). The study included 2,396 women with incident colorectal cancer, assessed for depressive symptoms and antidepressant use before cancer diagnosis at baseline (screening visit in the WHI study) during 1993–1998. Participants were followed up from cancer diagnosis till 2018. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HRs) between depression (depressive symptoms or antidepressant use) at baseline, and all-cause mortality and colorectal cancer-specific mortality. RESULTS: Among women with colorectal cancer, there was no association between baseline depression and all-cause mortality or colorectal cancer-specific mortality after adjusting for age or multiple covariates. CONCLUSION: Among women with colorectal cancer, there was no statistically significant association between depression before colorectal cancer diagnosis and all-cause mortality or colorectal cancer-specific mortality. Further studies are warranted to assess depressive symptoms and antidepressant use, measured at multiple points from baseline to diagnosis, and their interactions with specific types of colorectal cancer treatment on the risk of death from colorectal cancer. Public Library of Science 2020-12-31 /pmc/articles/PMC7774930/ /pubmed/33382778 http://dx.doi.org/10.1371/journal.pone.0244728 Text en © 2020 Liang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Liang, Xiaoyun Hendryx, Michael Qi, Lihong Lane, Dorothy Luo, Juhua Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer |
title | Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer |
title_full | Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer |
title_fullStr | Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer |
title_full_unstemmed | Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer |
title_short | Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer |
title_sort | association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774930/ https://www.ncbi.nlm.nih.gov/pubmed/33382778 http://dx.doi.org/10.1371/journal.pone.0244728 |
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