Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells

Ribonucleoside triphosphates are often incorporated into genomic DNA during DNA replication. The accumulation of unrepaired ribonucleotides is associated with genomic instability, which is mediated by DNA topoisomerase 1 (Top1) processing of embedded ribonucleotides. The cleavage initiated by Top1 a...

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Detalles Bibliográficos
Autores principales: Takeishi, Ayuna, Kogashi, Hiroyuki, Odagiri, Mizuki, Sasanuma, Hiroyuki, Takeda, Shunichi, Yasui, Manabu, Honma, Masamitsu, Suzuki, Tetsuya, Kamiya, Hiroyuki, Sugasawa, Kaoru, Ura, Kiyoe, Sassa, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775084/
https://www.ncbi.nlm.nih.gov/pubmed/33382846
http://dx.doi.org/10.1371/journal.pone.0244790

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