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Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological an...

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Detalles Bibliográficos
Autores principales: Gregorova, Michaela, Morse, Daniel, Brignoli, Tarcisio, Steventon, Joseph, Hamilton, Fergus, Albur, Mahableshwar, Arnold, David, Thomas, Matthew, Halliday, Alice, Baum, Holly, Rice, Christopher, Avison, Matthew B, Davidson, Andrew D, Santopaolo, Marianna, Oliver, Elizabeth, Goenka, Anu, Finn, Adam, Wooldridge, Linda, Amulic, Borko, Boyton, Rosemary J, Altmann, Daniel M, Butler, David K, McMurray, Claire, Stockton, Joanna, Nicholls, Sam, Cooper, Charles, Loman, Nicholas, Cox, Michael J, Rivino, Laura, Massey, Ruth C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775105/
https://www.ncbi.nlm.nih.gov/pubmed/33331820
http://dx.doi.org/10.7554/eLife.63430
Descripción
Sumario:Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.