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Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological an...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775105/ https://www.ncbi.nlm.nih.gov/pubmed/33331820 http://dx.doi.org/10.7554/eLife.63430 |
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| author | Gregorova, Michaela Morse, Daniel Brignoli, Tarcisio Steventon, Joseph Hamilton, Fergus Albur, Mahableshwar Arnold, David Thomas, Matthew Halliday, Alice Baum, Holly Rice, Christopher Avison, Matthew B Davidson, Andrew D Santopaolo, Marianna Oliver, Elizabeth Goenka, Anu Finn, Adam Wooldridge, Linda Amulic, Borko Boyton, Rosemary J Altmann, Daniel M Butler, David K McMurray, Claire Stockton, Joanna Nicholls, Sam Cooper, Charles Loman, Nicholas Cox, Michael J Rivino, Laura Massey, Ruth C |
| author_facet | Gregorova, Michaela Morse, Daniel Brignoli, Tarcisio Steventon, Joseph Hamilton, Fergus Albur, Mahableshwar Arnold, David Thomas, Matthew Halliday, Alice Baum, Holly Rice, Christopher Avison, Matthew B Davidson, Andrew D Santopaolo, Marianna Oliver, Elizabeth Goenka, Anu Finn, Adam Wooldridge, Linda Amulic, Borko Boyton, Rosemary J Altmann, Daniel M Butler, David K McMurray, Claire Stockton, Joanna Nicholls, Sam Cooper, Charles Loman, Nicholas Cox, Michael J Rivino, Laura Massey, Ruth C |
| author_sort | Gregorova, Michaela |
| collection | PubMed |
| description | Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes. |
| format | Online Article Text |
| id | pubmed-7775105 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77751052021-01-04 Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia Gregorova, Michaela Morse, Daniel Brignoli, Tarcisio Steventon, Joseph Hamilton, Fergus Albur, Mahableshwar Arnold, David Thomas, Matthew Halliday, Alice Baum, Holly Rice, Christopher Avison, Matthew B Davidson, Andrew D Santopaolo, Marianna Oliver, Elizabeth Goenka, Anu Finn, Adam Wooldridge, Linda Amulic, Borko Boyton, Rosemary J Altmann, Daniel M Butler, David K McMurray, Claire Stockton, Joanna Nicholls, Sam Cooper, Charles Loman, Nicholas Cox, Michael J Rivino, Laura Massey, Ruth C eLife Microbiology and Infectious Disease Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes. eLife Sciences Publications, Ltd 2020-12-17 /pmc/articles/PMC7775105/ /pubmed/33331820 http://dx.doi.org/10.7554/eLife.63430 Text en © 2020, Gregorova et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
| spellingShingle | Microbiology and Infectious Disease Gregorova, Michaela Morse, Daniel Brignoli, Tarcisio Steventon, Joseph Hamilton, Fergus Albur, Mahableshwar Arnold, David Thomas, Matthew Halliday, Alice Baum, Holly Rice, Christopher Avison, Matthew B Davidson, Andrew D Santopaolo, Marianna Oliver, Elizabeth Goenka, Anu Finn, Adam Wooldridge, Linda Amulic, Borko Boyton, Rosemary J Altmann, Daniel M Butler, David K McMurray, Claire Stockton, Joanna Nicholls, Sam Cooper, Charles Loman, Nicholas Cox, Michael J Rivino, Laura Massey, Ruth C Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia |
| title | Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia |
| title_full | Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia |
| title_fullStr | Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia |
| title_full_unstemmed | Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia |
| title_short | Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia |
| title_sort | post-acute covid-19 associated with evidence of bystander t-cell activation and a recurring antibiotic-resistant bacterial pneumonia |
| topic | Microbiology and Infectious Disease |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775105/ https://www.ncbi.nlm.nih.gov/pubmed/33331820 http://dx.doi.org/10.7554/eLife.63430 |
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