Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

Reverse transcription, an essential event in the HIV-1 life cycle, requires deoxynucleotide triphosphates (dNTPs) to fuel DNA synthesis, thus requiring penetration of dNTPs into the viral capsid. The central cavity of the capsid protein (CA) hexamer reveals itself as a plausible channel that allows...

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Detalles Bibliográficos
Autores principales: Xu, Chaoyi, Fischer, Douglas K., Rankovic, Sanela, Li, Wen, Dick, Robert A., Runge, Brent, Zadorozhnyi, Roman, Ahn, Jinwoo, Aiken, Christopher, Polenova, Tatyana, Engelman, Alan N., Ambrose, Zandrea, Rousso, Itay, Perilla, Juan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775124/
https://www.ncbi.nlm.nih.gov/pubmed/33332391
http://dx.doi.org/10.1371/journal.pbio.3001015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775124/
https://www.ncbi.nlm.nih.gov/pubmed/33332391
http://dx.doi.org/10.1371/journal.pbio.3001015

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