Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer's Disease by Binding with Catalase

Amyloid-beta (Aβ) is a critical etiological factor for late-onset familial Alzheimer's disease (AD). However, an early-onset AD has been found to be related with an Aβ mutation in glutamic acid 22-to-lysine (Italian type E22K). Why only one single point mutation at E22 residue induces AD remain...

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Detalles Bibliográficos
Autores principales: Jiang, Wenjing, YanYu, Yao, Dandan, Fei, Xuechao, Ai, Li, Di, Yalan, Zhang, Jingnan, Yue, Xiangpei, Zhao, Shengjie, He, Rongqiao, Lyu, Jihui, Tong, Zhiqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775154/
https://www.ncbi.nlm.nih.gov/pubmed/33425208
http://dx.doi.org/10.1155/2020/4981204

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