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Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction
Graft reconstruction of the mandible is an important approach that aims at improving the appearance and functionality of defected mandibles. The traditional implant materials are generally bioinert, non-degradable, and that they lack favorable pore structures for cell proliferation, which limit thei...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775478/ https://www.ncbi.nlm.nih.gov/pubmed/33392173 http://dx.doi.org/10.3389/fbioe.2020.610284 |
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author | Zhang, Peng Yang, Kang Zhou, Ziyu Zhu, Xingrong Li, Wenchao Cao, Chuanliang Zhou, Kui Liao, Lan Ai, Fanrong |
author_facet | Zhang, Peng Yang, Kang Zhou, Ziyu Zhu, Xingrong Li, Wenchao Cao, Chuanliang Zhou, Kui Liao, Lan Ai, Fanrong |
author_sort | Zhang, Peng |
collection | PubMed |
description | Graft reconstruction of the mandible is an important approach that aims at improving the appearance and functionality of defected mandibles. The traditional implant materials are generally bioinert, non-degradable, and that they lack favorable pore structures for cell proliferation, which limit their clinical application. In this study, we used boron-containing bioactive glass which was combined with a three-dimensional (3D) printing technology to construct an osteoinductive implant scaffold, according to the imaging instructions of CT scan on bone defects. Here, the boron-containing bioglass scaffold (B-BGs) was prepared through sol-gel processing and a 3D print technique. Different boron content of borosilicate bioglass was prepared by incorporating B(2)O(3) (molar: 19.4 and 38.8%) into 58S bioglass to replace parts of SiO(2). For fabricated mandible implants through three-dimensional 3D printing of B-BGs (size: 8 × 2 mm; pore size: 250 μm) modified with borosilicate bioglass powder and sodium alginate. Notably, the compressive strength of the B-BGs was about 3.8 Mpa, which supported mandibular activity. Subsequently, the excellent biocompatibility of B-BGs was confirmed using cytotoxicity in vitro studies. Finally, data from in vivo experiments demonstrated that the B-BGs could promote bone regeneration and they could almost get completely degraded within 4 weeks. Our results showed that the boron-containing bioglass could repair mandibular defects. |
format | Online Article Text |
id | pubmed-7775478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77754782021-01-02 Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction Zhang, Peng Yang, Kang Zhou, Ziyu Zhu, Xingrong Li, Wenchao Cao, Chuanliang Zhou, Kui Liao, Lan Ai, Fanrong Front Bioeng Biotechnol Bioengineering and Biotechnology Graft reconstruction of the mandible is an important approach that aims at improving the appearance and functionality of defected mandibles. The traditional implant materials are generally bioinert, non-degradable, and that they lack favorable pore structures for cell proliferation, which limit their clinical application. In this study, we used boron-containing bioactive glass which was combined with a three-dimensional (3D) printing technology to construct an osteoinductive implant scaffold, according to the imaging instructions of CT scan on bone defects. Here, the boron-containing bioglass scaffold (B-BGs) was prepared through sol-gel processing and a 3D print technique. Different boron content of borosilicate bioglass was prepared by incorporating B(2)O(3) (molar: 19.4 and 38.8%) into 58S bioglass to replace parts of SiO(2). For fabricated mandible implants through three-dimensional 3D printing of B-BGs (size: 8 × 2 mm; pore size: 250 μm) modified with borosilicate bioglass powder and sodium alginate. Notably, the compressive strength of the B-BGs was about 3.8 Mpa, which supported mandibular activity. Subsequently, the excellent biocompatibility of B-BGs was confirmed using cytotoxicity in vitro studies. Finally, data from in vivo experiments demonstrated that the B-BGs could promote bone regeneration and they could almost get completely degraded within 4 weeks. Our results showed that the boron-containing bioglass could repair mandibular defects. Frontiers Media S.A. 2020-12-18 /pmc/articles/PMC7775478/ /pubmed/33392173 http://dx.doi.org/10.3389/fbioe.2020.610284 Text en Copyright © 2020 Zhang, Yang, Zhou, Zhu, Li, Cao, Zhou, Liao and Ai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Zhang, Peng Yang, Kang Zhou, Ziyu Zhu, Xingrong Li, Wenchao Cao, Chuanliang Zhou, Kui Liao, Lan Ai, Fanrong Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction |
title | Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction |
title_full | Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction |
title_fullStr | Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction |
title_full_unstemmed | Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction |
title_short | Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction |
title_sort | customized borosilicate bioglass scaffolds with excellent biodegradation and osteogenesis for mandible reconstruction |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775478/ https://www.ncbi.nlm.nih.gov/pubmed/33392173 http://dx.doi.org/10.3389/fbioe.2020.610284 |
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