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Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity

Green nanotechnology has recently had a significant influence on advances in biological applications. The surface manipulation of iron oxide NPs by zinc oxide is increasing attention for biomedical research. Therefore, this work focused on the phytochemicals of creeper Blepharis maderaspantensis (BM...

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Autores principales: Abbas, Heba Salah, Krishnan, Akilandeswari, Kotakonda, Muddukrishnaiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775511/
https://www.ncbi.nlm.nih.gov/pubmed/33392168
http://dx.doi.org/10.3389/fbioe.2020.595161
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author Abbas, Heba Salah
Krishnan, Akilandeswari
Kotakonda, Muddukrishnaiah
author_facet Abbas, Heba Salah
Krishnan, Akilandeswari
Kotakonda, Muddukrishnaiah
author_sort Abbas, Heba Salah
collection PubMed
description Green nanotechnology has recently had a significant influence on advances in biological applications. The surface manipulation of iron oxide NPs by zinc oxide is increasing attention for biomedical research. Therefore, this work focused on the phytochemicals of creeper Blepharis maderaspantensis (BM) water extract for synthesizing iron oxide NPs and iron oxide/zinc oxide nanocomposite. The UV spectrum analysis showed a wavelength redshift from 294 to 302 nm of iron oxide/ZnO nanocomposite, and the polydispersity index revealed that the perfect preparations of iron oxide NPs were prepared by boiling 0.25 g of the plant in deionized water then the filtrate added to ferric chloride (1:1 v/v). The HRTEM results also illustrated that amorphous iron oxide NPs are spherical and irregular in shape. However, the iron oxide/ZnO nanocomposite showed a rod shape of ZnO with an average length and width of ∼19.25 ± 3.2 × 3.3 ± 0.6 nm surrounding amorphous iron oxide NPs. Furthermore, a high antimicrobial activity with MRSA and E. coli was demonstrated by iron oxide NPs. However, because of instability and negative surface charge of the iron oxide nanocomposite, there was no antimicrobial activity. Future cytotoxic studies of the iron oxide NPs synthesized with polyphenols of BM extract are desirable, and their applications in medical purposes will be recommended.
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spelling pubmed-77755112021-01-02 Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity Abbas, Heba Salah Krishnan, Akilandeswari Kotakonda, Muddukrishnaiah Front Bioeng Biotechnol Bioengineering and Biotechnology Green nanotechnology has recently had a significant influence on advances in biological applications. The surface manipulation of iron oxide NPs by zinc oxide is increasing attention for biomedical research. Therefore, this work focused on the phytochemicals of creeper Blepharis maderaspantensis (BM) water extract for synthesizing iron oxide NPs and iron oxide/zinc oxide nanocomposite. The UV spectrum analysis showed a wavelength redshift from 294 to 302 nm of iron oxide/ZnO nanocomposite, and the polydispersity index revealed that the perfect preparations of iron oxide NPs were prepared by boiling 0.25 g of the plant in deionized water then the filtrate added to ferric chloride (1:1 v/v). The HRTEM results also illustrated that amorphous iron oxide NPs are spherical and irregular in shape. However, the iron oxide/ZnO nanocomposite showed a rod shape of ZnO with an average length and width of ∼19.25 ± 3.2 × 3.3 ± 0.6 nm surrounding amorphous iron oxide NPs. Furthermore, a high antimicrobial activity with MRSA and E. coli was demonstrated by iron oxide NPs. However, because of instability and negative surface charge of the iron oxide nanocomposite, there was no antimicrobial activity. Future cytotoxic studies of the iron oxide NPs synthesized with polyphenols of BM extract are desirable, and their applications in medical purposes will be recommended. Frontiers Media S.A. 2020-12-18 /pmc/articles/PMC7775511/ /pubmed/33392168 http://dx.doi.org/10.3389/fbioe.2020.595161 Text en Copyright © 2020 Abbas, Krishnan and Kotakonda. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Abbas, Heba Salah
Krishnan, Akilandeswari
Kotakonda, Muddukrishnaiah
Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity
title Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity
title_full Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity
title_fullStr Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity
title_full_unstemmed Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity
title_short Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity
title_sort fabrication of iron oxide/zinc oxide nanocomposite using creeper blepharis maderaspatensis extract and their antimicrobial activity
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775511/
https://www.ncbi.nlm.nih.gov/pubmed/33392168
http://dx.doi.org/10.3389/fbioe.2020.595161
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