Cargando…
Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity
Green nanotechnology has recently had a significant influence on advances in biological applications. The surface manipulation of iron oxide NPs by zinc oxide is increasing attention for biomedical research. Therefore, this work focused on the phytochemicals of creeper Blepharis maderaspantensis (BM...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775511/ https://www.ncbi.nlm.nih.gov/pubmed/33392168 http://dx.doi.org/10.3389/fbioe.2020.595161 |
_version_ | 1783630483511312384 |
---|---|
author | Abbas, Heba Salah Krishnan, Akilandeswari Kotakonda, Muddukrishnaiah |
author_facet | Abbas, Heba Salah Krishnan, Akilandeswari Kotakonda, Muddukrishnaiah |
author_sort | Abbas, Heba Salah |
collection | PubMed |
description | Green nanotechnology has recently had a significant influence on advances in biological applications. The surface manipulation of iron oxide NPs by zinc oxide is increasing attention for biomedical research. Therefore, this work focused on the phytochemicals of creeper Blepharis maderaspantensis (BM) water extract for synthesizing iron oxide NPs and iron oxide/zinc oxide nanocomposite. The UV spectrum analysis showed a wavelength redshift from 294 to 302 nm of iron oxide/ZnO nanocomposite, and the polydispersity index revealed that the perfect preparations of iron oxide NPs were prepared by boiling 0.25 g of the plant in deionized water then the filtrate added to ferric chloride (1:1 v/v). The HRTEM results also illustrated that amorphous iron oxide NPs are spherical and irregular in shape. However, the iron oxide/ZnO nanocomposite showed a rod shape of ZnO with an average length and width of ∼19.25 ± 3.2 × 3.3 ± 0.6 nm surrounding amorphous iron oxide NPs. Furthermore, a high antimicrobial activity with MRSA and E. coli was demonstrated by iron oxide NPs. However, because of instability and negative surface charge of the iron oxide nanocomposite, there was no antimicrobial activity. Future cytotoxic studies of the iron oxide NPs synthesized with polyphenols of BM extract are desirable, and their applications in medical purposes will be recommended. |
format | Online Article Text |
id | pubmed-7775511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77755112021-01-02 Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity Abbas, Heba Salah Krishnan, Akilandeswari Kotakonda, Muddukrishnaiah Front Bioeng Biotechnol Bioengineering and Biotechnology Green nanotechnology has recently had a significant influence on advances in biological applications. The surface manipulation of iron oxide NPs by zinc oxide is increasing attention for biomedical research. Therefore, this work focused on the phytochemicals of creeper Blepharis maderaspantensis (BM) water extract for synthesizing iron oxide NPs and iron oxide/zinc oxide nanocomposite. The UV spectrum analysis showed a wavelength redshift from 294 to 302 nm of iron oxide/ZnO nanocomposite, and the polydispersity index revealed that the perfect preparations of iron oxide NPs were prepared by boiling 0.25 g of the plant in deionized water then the filtrate added to ferric chloride (1:1 v/v). The HRTEM results also illustrated that amorphous iron oxide NPs are spherical and irregular in shape. However, the iron oxide/ZnO nanocomposite showed a rod shape of ZnO with an average length and width of ∼19.25 ± 3.2 × 3.3 ± 0.6 nm surrounding amorphous iron oxide NPs. Furthermore, a high antimicrobial activity with MRSA and E. coli was demonstrated by iron oxide NPs. However, because of instability and negative surface charge of the iron oxide nanocomposite, there was no antimicrobial activity. Future cytotoxic studies of the iron oxide NPs synthesized with polyphenols of BM extract are desirable, and their applications in medical purposes will be recommended. Frontiers Media S.A. 2020-12-18 /pmc/articles/PMC7775511/ /pubmed/33392168 http://dx.doi.org/10.3389/fbioe.2020.595161 Text en Copyright © 2020 Abbas, Krishnan and Kotakonda. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Abbas, Heba Salah Krishnan, Akilandeswari Kotakonda, Muddukrishnaiah Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity |
title | Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity |
title_full | Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity |
title_fullStr | Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity |
title_full_unstemmed | Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity |
title_short | Fabrication of Iron Oxide/Zinc Oxide Nanocomposite Using Creeper Blepharis maderaspatensis Extract and Their Antimicrobial Activity |
title_sort | fabrication of iron oxide/zinc oxide nanocomposite using creeper blepharis maderaspatensis extract and their antimicrobial activity |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775511/ https://www.ncbi.nlm.nih.gov/pubmed/33392168 http://dx.doi.org/10.3389/fbioe.2020.595161 |
work_keys_str_mv | AT abbashebasalah fabricationofironoxidezincoxidenanocompositeusingcreeperblepharismaderaspatensisextractandtheirantimicrobialactivity AT krishnanakilandeswari fabricationofironoxidezincoxidenanocompositeusingcreeperblepharismaderaspatensisextractandtheirantimicrobialactivity AT kotakondamuddukrishnaiah fabricationofironoxidezincoxidenanocompositeusingcreeperblepharismaderaspatensisextractandtheirantimicrobialactivity |