Mitochondrial Deoxyguanosine Kinase Regulates NAD(+) Biogenesis Independent of Mitochondria Complex I Activity

Overexpression of DGUOK promotes mitochondria oxidative phosphorylation and lung adenocarcinoma progression. However, the role and mechanism of DGUOK in regulation of mitochondria function and lung cancer progression still poorly understood. Here we demonstrated that DGUOK regulated NAD(+) biogenesi...

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Detalles Bibliográficos
Autores principales: Sang, Lei, He, Ying-Jie, Kang, Jiaxin, Ye, Hongyi, Bai, Weiyu, Luo, Xiao-Dong, Sun, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775518/
https://www.ncbi.nlm.nih.gov/pubmed/33392072
http://dx.doi.org/10.3389/fonc.2020.570656

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