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Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor

OBJECTIVE: Although the treatment of glioblastoma patients is well established in neuro-oncological surgery, precious scarce data is available on patients with glioblastoma requiring postoperative prolonged mechanical ventilation (PMV). Therefore, the aim of the present study was to determine the in...

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Autores principales: Schuss, Patrick, Lehmann, Felix, Schäfer, Niklas, Bode, Christian, Scharnböck, Elisa, Schaub, Christina, Heimann, Muriel, Potthoff, Anna-Laura, Weller, Johannes, Güresir, Erdem, Putensen, Christian, Vatter, Hartmut, Herrlinger, Ulrich, Schneider, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775591/
https://www.ncbi.nlm.nih.gov/pubmed/33392096
http://dx.doi.org/10.3389/fonc.2020.607557
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author Schuss, Patrick
Lehmann, Felix
Schäfer, Niklas
Bode, Christian
Scharnböck, Elisa
Schaub, Christina
Heimann, Muriel
Potthoff, Anna-Laura
Weller, Johannes
Güresir, Erdem
Putensen, Christian
Vatter, Hartmut
Herrlinger, Ulrich
Schneider, Matthias
author_facet Schuss, Patrick
Lehmann, Felix
Schäfer, Niklas
Bode, Christian
Scharnböck, Elisa
Schaub, Christina
Heimann, Muriel
Potthoff, Anna-Laura
Weller, Johannes
Güresir, Erdem
Putensen, Christian
Vatter, Hartmut
Herrlinger, Ulrich
Schneider, Matthias
author_sort Schuss, Patrick
collection PubMed
description OBJECTIVE: Although the treatment of glioblastoma patients is well established in neuro-oncological surgery, precious scarce data is available on patients with glioblastoma requiring postoperative prolonged mechanical ventilation (PMV). Therefore, the aim of the present study was to determine the influence of PMV on overall survival (OS) in patients with glioblastoma. METHODS: Patients with newly diagnosed glioblastoma who had undergone surgical therapy and complete subsequent neuro-oncological treatment at the authors’ neuro-oncological center from January 2013 to December 2018 were selected and included in the further analysis. PMV was defined as mechanical ventilation for more than 24 h after surgery. Survival analyses were performed, including established prognostic factors such as age, Karnofsky performance score, MGMT-promoter methylation status and extent of resection. RESULTS: A total of 240 patients with newly diagnosed glioblastoma and subsequent surgical treatment were identified. 13 patients (5%) suffered from PMV during the treatment course of glioblastoma. All but one patient were successfully weaned from mechanical ventilation. Patients suffering from PMV achieved significantly less often favorable functional outcome after 3, 6, 9, and 12 months compared to patients without PMV. Multivariate analysis revealed PMV to constitute a significant prognostic factor for OS, independent of other prognostic factors (p<0.0001, OR 6.7, 95% CI 3.2–13.8). CONCLUSIONS: The present study identifies PMV as significantly associated with impaired functional outcome and poor OS in patients suffering from newly diagnosed glioblastoma. These findings encourage further efforts to investigate/assess this prognostic factor in future studies.
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spelling pubmed-77755912021-01-02 Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor Schuss, Patrick Lehmann, Felix Schäfer, Niklas Bode, Christian Scharnböck, Elisa Schaub, Christina Heimann, Muriel Potthoff, Anna-Laura Weller, Johannes Güresir, Erdem Putensen, Christian Vatter, Hartmut Herrlinger, Ulrich Schneider, Matthias Front Oncol Oncology OBJECTIVE: Although the treatment of glioblastoma patients is well established in neuro-oncological surgery, precious scarce data is available on patients with glioblastoma requiring postoperative prolonged mechanical ventilation (PMV). Therefore, the aim of the present study was to determine the influence of PMV on overall survival (OS) in patients with glioblastoma. METHODS: Patients with newly diagnosed glioblastoma who had undergone surgical therapy and complete subsequent neuro-oncological treatment at the authors’ neuro-oncological center from January 2013 to December 2018 were selected and included in the further analysis. PMV was defined as mechanical ventilation for more than 24 h after surgery. Survival analyses were performed, including established prognostic factors such as age, Karnofsky performance score, MGMT-promoter methylation status and extent of resection. RESULTS: A total of 240 patients with newly diagnosed glioblastoma and subsequent surgical treatment were identified. 13 patients (5%) suffered from PMV during the treatment course of glioblastoma. All but one patient were successfully weaned from mechanical ventilation. Patients suffering from PMV achieved significantly less often favorable functional outcome after 3, 6, 9, and 12 months compared to patients without PMV. Multivariate analysis revealed PMV to constitute a significant prognostic factor for OS, independent of other prognostic factors (p<0.0001, OR 6.7, 95% CI 3.2–13.8). CONCLUSIONS: The present study identifies PMV as significantly associated with impaired functional outcome and poor OS in patients suffering from newly diagnosed glioblastoma. These findings encourage further efforts to investigate/assess this prognostic factor in future studies. Frontiers Media S.A. 2020-12-18 /pmc/articles/PMC7775591/ /pubmed/33392096 http://dx.doi.org/10.3389/fonc.2020.607557 Text en Copyright © 2020 Schuss, Lehmann, Schäfer, Bode, Scharnböck, Schaub, Heimann, Potthoff, Weller, Güresir, Putensen, Vatter, Herrlinger and Schneider http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Schuss, Patrick
Lehmann, Felix
Schäfer, Niklas
Bode, Christian
Scharnböck, Elisa
Schaub, Christina
Heimann, Muriel
Potthoff, Anna-Laura
Weller, Johannes
Güresir, Erdem
Putensen, Christian
Vatter, Hartmut
Herrlinger, Ulrich
Schneider, Matthias
Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor
title Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor
title_full Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor
title_fullStr Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor
title_full_unstemmed Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor
title_short Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor
title_sort postoperative prolonged mechanical ventilation in patients with newly diagnosed glioblastoma—an unrecognized prognostic factor
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775591/
https://www.ncbi.nlm.nih.gov/pubmed/33392096
http://dx.doi.org/10.3389/fonc.2020.607557
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