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Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease

The pathological relevance of naturally occurring antibodies to β-amyloid (NAbs-Aβ) in Alzheimer’s disease (AD) remains unclear. We aimed to investigate their levels and associations with Aβ burden and cognitive decline in AD in a cross-sectional cohort from China and a longitudinal cohort from the...

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Autores principales: Liu, Yu-Hui, Wang, Jun, Li, Qiao-Xin, Fowler, Christopher J., Zeng, Fan, Deng, Juan, Xu, Zhi-Qiang, Zhou, Hua-Dong, Doecke, James D., Villemagne, Victor L., Lim, Yen Ying, Masters, Colin L., Wang, Yan-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775771/
https://www.ncbi.nlm.nih.gov/pubmed/33523832
http://dx.doi.org/10.1126/sciadv.abb0457
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author Liu, Yu-Hui
Wang, Jun
Li, Qiao-Xin
Fowler, Christopher J.
Zeng, Fan
Deng, Juan
Xu, Zhi-Qiang
Zhou, Hua-Dong
Doecke, James D.
Villemagne, Victor L.
Lim, Yen Ying
Masters, Colin L.
Wang, Yan-Jiang
author_facet Liu, Yu-Hui
Wang, Jun
Li, Qiao-Xin
Fowler, Christopher J.
Zeng, Fan
Deng, Juan
Xu, Zhi-Qiang
Zhou, Hua-Dong
Doecke, James D.
Villemagne, Victor L.
Lim, Yen Ying
Masters, Colin L.
Wang, Yan-Jiang
author_sort Liu, Yu-Hui
collection PubMed
description The pathological relevance of naturally occurring antibodies to β-amyloid (NAbs-Aβ) in Alzheimer’s disease (AD) remains unclear. We aimed to investigate their levels and associations with Aβ burden and cognitive decline in AD in a cross-sectional cohort from China and a longitudinal cohort from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. NAbs-Aβ levels in plasma and cerebrospinal fluid (CSF) were tested according to their epitopes. Levels of NAbs targeting the amino terminus of Aβ increased, and those targeting the mid-domain of Aβ decreased in both CSF and plasma in AD patients. Higher plasma levels of NAbs targeting the amino terminus of Aβ and lower plasma levels of NAbs targeting the mid-domain of Aβ were associated with higher brain amyloidosis at baseline and faster cognitive decline during follow-up. Our findings suggest a dynamic response of the adaptive immune system in the progression of AD and are relevant to current passive immunotherapeutic strategies.
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spelling pubmed-77757712021-01-14 Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease Liu, Yu-Hui Wang, Jun Li, Qiao-Xin Fowler, Christopher J. Zeng, Fan Deng, Juan Xu, Zhi-Qiang Zhou, Hua-Dong Doecke, James D. Villemagne, Victor L. Lim, Yen Ying Masters, Colin L. Wang, Yan-Jiang Sci Adv Research Articles The pathological relevance of naturally occurring antibodies to β-amyloid (NAbs-Aβ) in Alzheimer’s disease (AD) remains unclear. We aimed to investigate their levels and associations with Aβ burden and cognitive decline in AD in a cross-sectional cohort from China and a longitudinal cohort from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. NAbs-Aβ levels in plasma and cerebrospinal fluid (CSF) were tested according to their epitopes. Levels of NAbs targeting the amino terminus of Aβ increased, and those targeting the mid-domain of Aβ decreased in both CSF and plasma in AD patients. Higher plasma levels of NAbs targeting the amino terminus of Aβ and lower plasma levels of NAbs targeting the mid-domain of Aβ were associated with higher brain amyloidosis at baseline and faster cognitive decline during follow-up. Our findings suggest a dynamic response of the adaptive immune system in the progression of AD and are relevant to current passive immunotherapeutic strategies. American Association for the Advancement of Science 2021-01-01 /pmc/articles/PMC7775771/ /pubmed/33523832 http://dx.doi.org/10.1126/sciadv.abb0457 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Liu, Yu-Hui
Wang, Jun
Li, Qiao-Xin
Fowler, Christopher J.
Zeng, Fan
Deng, Juan
Xu, Zhi-Qiang
Zhou, Hua-Dong
Doecke, James D.
Villemagne, Victor L.
Lim, Yen Ying
Masters, Colin L.
Wang, Yan-Jiang
Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease
title Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease
title_full Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease
title_fullStr Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease
title_full_unstemmed Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease
title_short Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease
title_sort association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in alzheimer’s disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775771/
https://www.ncbi.nlm.nih.gov/pubmed/33523832
http://dx.doi.org/10.1126/sciadv.abb0457
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