Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response

Phosphorylcholine monoclonal immunoglobulin G antibody attenuates the immediate post-ischemic inflammatory response by reducing the proinflammatory chemokine (C-C motif) ligand 2 chemokine and circulating Ly-6C(hi) monocytes. This subsequently enhances the post-ischemic repair process, resulting in...

Descripción completa

Detalles Bibliográficos
Autores principales: Pluijmert, Niek J., de Jong, Rob C.M., de Vries, Margreet R., Pettersson, Knut, Atsma, Douwe E., Jukema, J. Wouter, Quax, Paul H.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775955/
https://www.ncbi.nlm.nih.gov/pubmed/33426378
http://dx.doi.org/10.1016/j.jacbts.2020.09.012
_version_ 1783630571463770112
author Pluijmert, Niek J.
de Jong, Rob C.M.
de Vries, Margreet R.
Pettersson, Knut
Atsma, Douwe E.
Jukema, J. Wouter
Quax, Paul H.A.
author_facet Pluijmert, Niek J.
de Jong, Rob C.M.
de Vries, Margreet R.
Pettersson, Knut
Atsma, Douwe E.
Jukema, J. Wouter
Quax, Paul H.A.
author_sort Pluijmert, Niek J.
collection PubMed
description Phosphorylcholine monoclonal immunoglobulin G antibody attenuates the immediate post-ischemic inflammatory response by reducing the proinflammatory chemokine (C-C motif) ligand 2 chemokine and circulating Ly-6C(hi) monocytes. This subsequently enhances the post-ischemic repair process, resulting in limited adverse cardiac remodeling and preservation of cardiac function. Therefore, phosphorylcholine monoclonal immunoglobulin G antibody therapy may be a valid therapeutic approach against myocardial ischemia-reperfusion injury.
format Online
Article
Text
id pubmed-7775955
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-77759552021-01-07 Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response Pluijmert, Niek J. de Jong, Rob C.M. de Vries, Margreet R. Pettersson, Knut Atsma, Douwe E. Jukema, J. Wouter Quax, Paul H.A. JACC Basic Transl Sci Preclinical Research Phosphorylcholine monoclonal immunoglobulin G antibody attenuates the immediate post-ischemic inflammatory response by reducing the proinflammatory chemokine (C-C motif) ligand 2 chemokine and circulating Ly-6C(hi) monocytes. This subsequently enhances the post-ischemic repair process, resulting in limited adverse cardiac remodeling and preservation of cardiac function. Therefore, phosphorylcholine monoclonal immunoglobulin G antibody therapy may be a valid therapeutic approach against myocardial ischemia-reperfusion injury. Elsevier 2020-12-02 /pmc/articles/PMC7775955/ /pubmed/33426378 http://dx.doi.org/10.1016/j.jacbts.2020.09.012 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preclinical Research
Pluijmert, Niek J.
de Jong, Rob C.M.
de Vries, Margreet R.
Pettersson, Knut
Atsma, Douwe E.
Jukema, J. Wouter
Quax, Paul H.A.
Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response
title Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response
title_full Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response
title_fullStr Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response
title_full_unstemmed Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response
title_short Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response
title_sort phosphorylcholine antibodies preserve cardiac function and reduce infarct size by attenuating the post-ischemic inflammatory response
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775955/
https://www.ncbi.nlm.nih.gov/pubmed/33426378
http://dx.doi.org/10.1016/j.jacbts.2020.09.012
work_keys_str_mv AT pluijmertniekj phosphorylcholineantibodiespreservecardiacfunctionandreduceinfarctsizebyattenuatingthepostischemicinflammatoryresponse
AT dejongrobcm phosphorylcholineantibodiespreservecardiacfunctionandreduceinfarctsizebyattenuatingthepostischemicinflammatoryresponse
AT devriesmargreetr phosphorylcholineantibodiespreservecardiacfunctionandreduceinfarctsizebyattenuatingthepostischemicinflammatoryresponse
AT petterssonknut phosphorylcholineantibodiespreservecardiacfunctionandreduceinfarctsizebyattenuatingthepostischemicinflammatoryresponse
AT atsmadouwee phosphorylcholineantibodiespreservecardiacfunctionandreduceinfarctsizebyattenuatingthepostischemicinflammatoryresponse
AT jukemajwouter phosphorylcholineantibodiespreservecardiacfunctionandreduceinfarctsizebyattenuatingthepostischemicinflammatoryresponse
AT quaxpaulha phosphorylcholineantibodiespreservecardiacfunctionandreduceinfarctsizebyattenuatingthepostischemicinflammatoryresponse

Ejemplares similares