Cargando…
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function following MI, in mice deficient for the NLRP3 inflammasome, can be recapitulate...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775960/ https://www.ncbi.nlm.nih.gov/pubmed/33426377 http://dx.doi.org/10.1016/j.jacbts.2020.09.013 |
| _version_ | 1783630572373934080 |
|---|---|
| author | Louwe, Mieke C. Olsen, Maria B. Kaasbøll, Ole J. Yang, Kuan Fosshaug, Linn E. Alfsnes, Katrine Øgaard, Jonas D.S. Rashidi, Azita Skulberg, Vidar M. Yang, Mingyi de Miranda Fonseca, Davi Sharma, Animesh Aronsen, Jan Magnus Schrumpf, Elisabeth Ahmed, Muhammad Shakil Dahl, Christen Peder Nyman, Tuula A. Ueland, Thor Melum, Espen Halvorsen, Bente E. Bjørås, Magnar Attramadal, Håvard Sjaastad, Ivar Aukrust, Pål Yndestad, Arne |
| author_facet | Louwe, Mieke C. Olsen, Maria B. Kaasbøll, Ole J. Yang, Kuan Fosshaug, Linn E. Alfsnes, Katrine Øgaard, Jonas D.S. Rashidi, Azita Skulberg, Vidar M. Yang, Mingyi de Miranda Fonseca, Davi Sharma, Animesh Aronsen, Jan Magnus Schrumpf, Elisabeth Ahmed, Muhammad Shakil Dahl, Christen Peder Nyman, Tuula A. Ueland, Thor Melum, Espen Halvorsen, Bente E. Bjørås, Magnar Attramadal, Håvard Sjaastad, Ivar Aukrust, Pål Yndestad, Arne |
| author_sort | Louwe, Mieke C. |
| collection | PubMed |
| description | An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function following MI, in mice deficient for the NLRP3 inflammasome, can be recapitulated in wild-type mice receiving bone marrow from Nlrp3(−/−) mice. This suggests that NLRP3 activation in hematopoietic cells infiltrating in the myocardium increases mortality and late ventricular remodeling. Our data should encourage performing clinical trials directly targeting NLRP3 inflammasome and their inflammatory cytokines (interleukin-1β and -18) in MI patients. |
| format | Online Article Text |
| id | pubmed-7775960 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77759602021-01-07 Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction Louwe, Mieke C. Olsen, Maria B. Kaasbøll, Ole J. Yang, Kuan Fosshaug, Linn E. Alfsnes, Katrine Øgaard, Jonas D.S. Rashidi, Azita Skulberg, Vidar M. Yang, Mingyi de Miranda Fonseca, Davi Sharma, Animesh Aronsen, Jan Magnus Schrumpf, Elisabeth Ahmed, Muhammad Shakil Dahl, Christen Peder Nyman, Tuula A. Ueland, Thor Melum, Espen Halvorsen, Bente E. Bjørås, Magnar Attramadal, Håvard Sjaastad, Ivar Aukrust, Pål Yndestad, Arne JACC Basic Transl Sci Preclinical Research An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function following MI, in mice deficient for the NLRP3 inflammasome, can be recapitulated in wild-type mice receiving bone marrow from Nlrp3(−/−) mice. This suggests that NLRP3 activation in hematopoietic cells infiltrating in the myocardium increases mortality and late ventricular remodeling. Our data should encourage performing clinical trials directly targeting NLRP3 inflammasome and their inflammatory cytokines (interleukin-1β and -18) in MI patients. Elsevier 2020-12-09 /pmc/articles/PMC7775960/ /pubmed/33426377 http://dx.doi.org/10.1016/j.jacbts.2020.09.013 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preclinical Research Louwe, Mieke C. Olsen, Maria B. Kaasbøll, Ole J. Yang, Kuan Fosshaug, Linn E. Alfsnes, Katrine Øgaard, Jonas D.S. Rashidi, Azita Skulberg, Vidar M. Yang, Mingyi de Miranda Fonseca, Davi Sharma, Animesh Aronsen, Jan Magnus Schrumpf, Elisabeth Ahmed, Muhammad Shakil Dahl, Christen Peder Nyman, Tuula A. Ueland, Thor Melum, Espen Halvorsen, Bente E. Bjørås, Magnar Attramadal, Håvard Sjaastad, Ivar Aukrust, Pål Yndestad, Arne Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction |
| title | Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction |
| title_full | Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction |
| title_fullStr | Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction |
| title_full_unstemmed | Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction |
| title_short | Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction |
| title_sort | absence of nlrp3 inflammasome in hematopoietic cells reduces adverse remodeling after experimental myocardial infarction |
| topic | Preclinical Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775960/ https://www.ncbi.nlm.nih.gov/pubmed/33426377 http://dx.doi.org/10.1016/j.jacbts.2020.09.013 |
| work_keys_str_mv | AT louwemiekec absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT olsenmariab absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT kaasbøllolej absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT yangkuan absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT fosshauglinne absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT alfsneskatrine absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT øgaardjonasds absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT rashidiazita absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT skulbergvidarm absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT yangmingyi absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT demirandafonsecadavi absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT sharmaanimesh absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT aronsenjanmagnus absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT schrumpfelisabeth absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT ahmedmuhammadshakil absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT dahlchristenpeder absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT nymantuulaa absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT uelandthor absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT melumespen absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT halvorsenbentee absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT bjørasmagnar absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT attramadalhavard absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT sjaastadivar absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT aukrustpal absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction AT yndestadarne absenceofnlrp3inflammasomeinhematopoieticcellsreducesadverseremodelingafterexperimentalmyocardialinfarction |