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Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study

Persisting asymmetry of motor symptoms are characteristic of Parkinson's disease (PD). We investigated the possible lateralized effects on regional cerebral blood flow (CBF), CBF‐connectivity, and laterality index (LI) among PD subtypes using arterial spin labeling (ASL). Forty‐four left‐sided...

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Autores principales: Shang, Song'an, Wu, Jingtao, Zhang, Hongying, Chen, Hongri, Cao, Zhengye, Chen, Yu‐Chen, Yin, Xindao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775999/
https://www.ncbi.nlm.nih.gov/pubmed/33017507
http://dx.doi.org/10.1002/hbm.25223
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author Shang, Song'an
Wu, Jingtao
Zhang, Hongying
Chen, Hongri
Cao, Zhengye
Chen, Yu‐Chen
Yin, Xindao
author_facet Shang, Song'an
Wu, Jingtao
Zhang, Hongying
Chen, Hongri
Cao, Zhengye
Chen, Yu‐Chen
Yin, Xindao
author_sort Shang, Song'an
collection PubMed
description Persisting asymmetry of motor symptoms are characteristic of Parkinson's disease (PD). We investigated the possible lateralized effects on regional cerebral blood flow (CBF), CBF‐connectivity, and laterality index (LI) among PD subtypes using arterial spin labeling (ASL). Forty‐four left‐sided symptom dominance patients (PDL), forty‐eight right‐sided symptom dominance patients (PDR), and forty‐five matched HCs were included. Group comparisons were performed for the regional normalized CBF, CBF‐connectivity and LI of basal ganglia (BA) subregions. The PDL patients had lower CBF in right calcarine sulcus and right supramarginal gyrus compared to the PDR and the HC subjects. Regional perfusion alterations seemed more extensive in the PDL than in the PDR group. In the PDL, correlations were identified between right thalamus and motor severity, between right fusiform gyrus and global cognitive performance. None of correlations survived after multiple comparisons correction. The significantly altered CBF‐connectivity among the three groups included: unilateral putamen, unilateral globus pallidus, and right thalamus. LI score in the putamen was significantly different among groups. Motor‐symptom laterality in PD may exhibit asymmetric regional and interregional abnormalities of CBF properties, particularly in PDL patients. This preliminary study underlines the necessity of classifying PD subgroups based on asymmetric motor symptoms and the potential application of CBF properties underlying neuropathology in PD.
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spelling pubmed-77759992021-01-07 Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study Shang, Song'an Wu, Jingtao Zhang, Hongying Chen, Hongri Cao, Zhengye Chen, Yu‐Chen Yin, Xindao Hum Brain Mapp Research Articles Persisting asymmetry of motor symptoms are characteristic of Parkinson's disease (PD). We investigated the possible lateralized effects on regional cerebral blood flow (CBF), CBF‐connectivity, and laterality index (LI) among PD subtypes using arterial spin labeling (ASL). Forty‐four left‐sided symptom dominance patients (PDL), forty‐eight right‐sided symptom dominance patients (PDR), and forty‐five matched HCs were included. Group comparisons were performed for the regional normalized CBF, CBF‐connectivity and LI of basal ganglia (BA) subregions. The PDL patients had lower CBF in right calcarine sulcus and right supramarginal gyrus compared to the PDR and the HC subjects. Regional perfusion alterations seemed more extensive in the PDL than in the PDR group. In the PDL, correlations were identified between right thalamus and motor severity, between right fusiform gyrus and global cognitive performance. None of correlations survived after multiple comparisons correction. The significantly altered CBF‐connectivity among the three groups included: unilateral putamen, unilateral globus pallidus, and right thalamus. LI score in the putamen was significantly different among groups. Motor‐symptom laterality in PD may exhibit asymmetric regional and interregional abnormalities of CBF properties, particularly in PDL patients. This preliminary study underlines the necessity of classifying PD subgroups based on asymmetric motor symptoms and the potential application of CBF properties underlying neuropathology in PD. John Wiley & Sons, Inc. 2020-10-05 /pmc/articles/PMC7775999/ /pubmed/33017507 http://dx.doi.org/10.1002/hbm.25223 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Shang, Song'an
Wu, Jingtao
Zhang, Hongying
Chen, Hongri
Cao, Zhengye
Chen, Yu‐Chen
Yin, Xindao
Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study
title Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study
title_full Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study
title_fullStr Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study
title_full_unstemmed Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study
title_short Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study
title_sort motor asymmetry related cerebral perfusion patterns in parkinson's disease: an arterial spin labeling study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775999/
https://www.ncbi.nlm.nih.gov/pubmed/33017507
http://dx.doi.org/10.1002/hbm.25223
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