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Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study
Persisting asymmetry of motor symptoms are characteristic of Parkinson's disease (PD). We investigated the possible lateralized effects on regional cerebral blood flow (CBF), CBF‐connectivity, and laterality index (LI) among PD subtypes using arterial spin labeling (ASL). Forty‐four left‐sided...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775999/ https://www.ncbi.nlm.nih.gov/pubmed/33017507 http://dx.doi.org/10.1002/hbm.25223 |
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author | Shang, Song'an Wu, Jingtao Zhang, Hongying Chen, Hongri Cao, Zhengye Chen, Yu‐Chen Yin, Xindao |
author_facet | Shang, Song'an Wu, Jingtao Zhang, Hongying Chen, Hongri Cao, Zhengye Chen, Yu‐Chen Yin, Xindao |
author_sort | Shang, Song'an |
collection | PubMed |
description | Persisting asymmetry of motor symptoms are characteristic of Parkinson's disease (PD). We investigated the possible lateralized effects on regional cerebral blood flow (CBF), CBF‐connectivity, and laterality index (LI) among PD subtypes using arterial spin labeling (ASL). Forty‐four left‐sided symptom dominance patients (PDL), forty‐eight right‐sided symptom dominance patients (PDR), and forty‐five matched HCs were included. Group comparisons were performed for the regional normalized CBF, CBF‐connectivity and LI of basal ganglia (BA) subregions. The PDL patients had lower CBF in right calcarine sulcus and right supramarginal gyrus compared to the PDR and the HC subjects. Regional perfusion alterations seemed more extensive in the PDL than in the PDR group. In the PDL, correlations were identified between right thalamus and motor severity, between right fusiform gyrus and global cognitive performance. None of correlations survived after multiple comparisons correction. The significantly altered CBF‐connectivity among the three groups included: unilateral putamen, unilateral globus pallidus, and right thalamus. LI score in the putamen was significantly different among groups. Motor‐symptom laterality in PD may exhibit asymmetric regional and interregional abnormalities of CBF properties, particularly in PDL patients. This preliminary study underlines the necessity of classifying PD subgroups based on asymmetric motor symptoms and the potential application of CBF properties underlying neuropathology in PD. |
format | Online Article Text |
id | pubmed-7775999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77759992021-01-07 Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study Shang, Song'an Wu, Jingtao Zhang, Hongying Chen, Hongri Cao, Zhengye Chen, Yu‐Chen Yin, Xindao Hum Brain Mapp Research Articles Persisting asymmetry of motor symptoms are characteristic of Parkinson's disease (PD). We investigated the possible lateralized effects on regional cerebral blood flow (CBF), CBF‐connectivity, and laterality index (LI) among PD subtypes using arterial spin labeling (ASL). Forty‐four left‐sided symptom dominance patients (PDL), forty‐eight right‐sided symptom dominance patients (PDR), and forty‐five matched HCs were included. Group comparisons were performed for the regional normalized CBF, CBF‐connectivity and LI of basal ganglia (BA) subregions. The PDL patients had lower CBF in right calcarine sulcus and right supramarginal gyrus compared to the PDR and the HC subjects. Regional perfusion alterations seemed more extensive in the PDL than in the PDR group. In the PDL, correlations were identified between right thalamus and motor severity, between right fusiform gyrus and global cognitive performance. None of correlations survived after multiple comparisons correction. The significantly altered CBF‐connectivity among the three groups included: unilateral putamen, unilateral globus pallidus, and right thalamus. LI score in the putamen was significantly different among groups. Motor‐symptom laterality in PD may exhibit asymmetric regional and interregional abnormalities of CBF properties, particularly in PDL patients. This preliminary study underlines the necessity of classifying PD subgroups based on asymmetric motor symptoms and the potential application of CBF properties underlying neuropathology in PD. John Wiley & Sons, Inc. 2020-10-05 /pmc/articles/PMC7775999/ /pubmed/33017507 http://dx.doi.org/10.1002/hbm.25223 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Shang, Song'an Wu, Jingtao Zhang, Hongying Chen, Hongri Cao, Zhengye Chen, Yu‐Chen Yin, Xindao Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study |
title | Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study |
title_full | Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study |
title_fullStr | Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study |
title_full_unstemmed | Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study |
title_short | Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study |
title_sort | motor asymmetry related cerebral perfusion patterns in parkinson's disease: an arterial spin labeling study |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775999/ https://www.ncbi.nlm.nih.gov/pubmed/33017507 http://dx.doi.org/10.1002/hbm.25223 |
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