The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission

Chronic myeloid leukemia arises from the transformation of hematopoietic stem cells by the BCR-ABL oncogene. Though transformed cells are predominantly BCR-ABL-dependent and sensitive to tyrosine kinase inhibitor treatment, some BMPR1B(+) leukemic stem cells are treatment-insensitive and rely, among...

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Detalles Bibliográficos
Autores principales: Jeanpierre, Sandrine, Arizkane, Kawtar, Thongjuea, Supat, Grockowiak, Elodie, Geistlich, Kevin, Barral, Lea, Voeltzel, Thibault, Guillemin, Anissa, Gonin-Giraud, Sandrine, Gandrillon, Olivier, Nicolini, Franck-Emmanuel, Mead, Adam J., Maguer-Satta, Véronique, Lefort, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776261/
https://www.ncbi.nlm.nih.gov/pubmed/32001529
http://dx.doi.org/10.3324/haematol.2019.232793

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