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Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain
BACKGROUND: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. CASE: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antib...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776280/ https://www.ncbi.nlm.nih.gov/pubmed/33387262 http://dx.doi.org/10.1007/s15010-020-01556-8 |
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| author | Billon-Denis, Emmanuelle Ferrier-Rembert, Audrey Garnier, Annabelle Cheutin, Laurence Vigne, Clarisse Tessier, Emilie Denis, Jessica Badaut, Cyril Rougeaux, Clémence Depeille Wuille, Anne Timera, Hawa Boutin, Laet itia Drouet, Isabelle Verguet, Noémie Nolent, Flora Gorgé, Olivier Ferraris, Olivier Tournier, Jean-Nicolas |
| author_facet | Billon-Denis, Emmanuelle Ferrier-Rembert, Audrey Garnier, Annabelle Cheutin, Laurence Vigne, Clarisse Tessier, Emilie Denis, Jessica Badaut, Cyril Rougeaux, Clémence Depeille Wuille, Anne Timera, Hawa Boutin, Laet itia Drouet, Isabelle Verguet, Noémie Nolent, Flora Gorgé, Olivier Ferraris, Olivier Tournier, Jean-Nicolas |
| author_sort | Billon-Denis, Emmanuelle |
| collection | PubMed |
| description | BACKGROUND: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. CASE: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers. DISCUSSION AND CONCLUSION: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity. |
| format | Online Article Text |
| id | pubmed-7776280 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Springer Berlin Heidelberg |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77762802021-01-04 Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain Billon-Denis, Emmanuelle Ferrier-Rembert, Audrey Garnier, Annabelle Cheutin, Laurence Vigne, Clarisse Tessier, Emilie Denis, Jessica Badaut, Cyril Rougeaux, Clémence Depeille Wuille, Anne Timera, Hawa Boutin, Laet itia Drouet, Isabelle Verguet, Noémie Nolent, Flora Gorgé, Olivier Ferraris, Olivier Tournier, Jean-Nicolas Infection Case Report BACKGROUND: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. CASE: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers. DISCUSSION AND CONCLUSION: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity. Springer Berlin Heidelberg 2021-01-02 2021 /pmc/articles/PMC7776280/ /pubmed/33387262 http://dx.doi.org/10.1007/s15010-020-01556-8 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Case Report Billon-Denis, Emmanuelle Ferrier-Rembert, Audrey Garnier, Annabelle Cheutin, Laurence Vigne, Clarisse Tessier, Emilie Denis, Jessica Badaut, Cyril Rougeaux, Clémence Depeille Wuille, Anne Timera, Hawa Boutin, Laet itia Drouet, Isabelle Verguet, Noémie Nolent, Flora Gorgé, Olivier Ferraris, Olivier Tournier, Jean-Nicolas Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain |
| title | Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain |
| title_full | Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain |
| title_fullStr | Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain |
| title_full_unstemmed | Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain |
| title_short | Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain |
| title_sort | differential serological and neutralizing antibody dynamics after an infection by a single sars-cov-2 strain |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776280/ https://www.ncbi.nlm.nih.gov/pubmed/33387262 http://dx.doi.org/10.1007/s15010-020-01556-8 |
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