1263. Assessment of Cefepime (FEP)-Taniborbactam (TAN) Human Exposures to Suppress the Emergence of Resistance among Serine (SBL)- and Metallo-β-Lactamase (MBL)-Producing Gram-Negative Bacteria (GNB) in a Hollow Fiber Infection Model (HFIM)

BACKGROUND: FEP-TAN (FTB) efficacy and safety are currently being evaluated in a Phase 3 trial (NCT03840148). TAN, a boronic acid-based β-lactamase inhibitor, restores susceptibility to FEP when resistance is driven by SBL or MBL (ie, NDM, VIM). This in vitro study assessed whether clinical FTB expo...

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Detalles Bibliográficos
Autores principales: Avery, Lindsay M, Vernacchio, Salvador, McLaughlin, Lisa, Xerri, Luigi, Moeck, Greg, Pevear, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776537/
http://dx.doi.org/10.1093/ofid/ofaa439.1447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776537/
http://dx.doi.org/10.1093/ofid/ofaa439.1447

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