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Allosteric cooperation in a de novo-designed two-domain protein

We describe the de novo design of an allosterically regulated protein, which comprises two tightly coupled domains. One domain is based on the DF (Due Ferri in Italian or two-iron in English) family of de novo proteins, which have a diiron cofactor that catalyzes a phenol oxidase reaction, while the...

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Detalles Bibliográficos
Autores principales:	Pirro, Fabio, Schmidt, Nathan, Lincoff, James, Widel, Zachary X., Polizzi, Nicholas F., Liu, Lijun, Therien, Michael J., Grabe, Michael, Chino, Marco, Lombardi, Angela, DeGrado, William F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776816/ https://www.ncbi.nlm.nih.gov/pubmed/33318174 http://dx.doi.org/10.1073/pnas.2017062117

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