Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

Intraocular pressure-sensitive retinal ganglion cell degeneration is a hallmark of glaucoma, the leading cause of irreversible blindness. Here, we used RNA-sequencing and metabolomics to examine early glaucoma in DBA/2J mice. We demonstrate gene expression changes that significantly impact pathways...

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Detalles Bibliográficos
Autores principales: Harder, Jeffrey M., Guymer, Chelsea, Wood, John P. M., Daskalaki, Evangelia, Chidlow, Glyn, Zhang, Chi, Balasubramanian, Revathi, Cardozo, Brynn H., Foxworth, Nicole E., Deering, Kelly E., Ouellette, Tionna B., Montgomery, Christa, Wheelock, Craig E., Casson, Robert J., Williams, Pete A., John, Simon W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776900/
https://www.ncbi.nlm.nih.gov/pubmed/33318177
http://dx.doi.org/10.1073/pnas.2014213117

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