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Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin

Retinoblastoma (Rb) is the most prevalent intraocular malignancy in children, with a worldwide survival rate <30%. We have developed a cancerous model of Rb in retinal organoids derived from genetically engineered human embryonic stem cells (hESCs) with a biallelic mutagenesis of the RB1 gene. Th...

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Detalles Bibliográficos
Autores principales:	Liu, Hui, Zhang, Yan, Zhang, You-You, Li, Yan-Ping, Hua, Zi-Qi, Zhang, Chang-Jun, Wu, Kun-Chao, Yu, Fulong, Zhang, Yaru, Su, Jianzhong, Jin, Zi-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776986/ https://www.ncbi.nlm.nih.gov/pubmed/33318192 http://dx.doi.org/10.1073/pnas.2011780117

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