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544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region
BACKGROUND: Children and young adults were initially reported as largely spared from severe complications of SARS-CoV-2 infection, but the impact to this population has been significant. METHODS: This observational retrospective cohort study includes 420 symptomatic children and young adults with la...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776997/ http://dx.doi.org/10.1093/ofid/ofaa439.738 |
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author | DeBiasi, Roberta L Song, Xiaoyan Ansusinha, Emily Smith, Karen L Bell, Michael Pershad, Jay Hahn, Andrea Hamdy, Rana Hanisch, Benjamin Harik, Nada Jantausch, Barbara A Koay, Adeline Campos, Joseph M Delaney, Meghan Simpson, Joelle Cora-Bramble, Denice Wessel, David |
author_facet | DeBiasi, Roberta L Song, Xiaoyan Ansusinha, Emily Smith, Karen L Bell, Michael Pershad, Jay Hahn, Andrea Hamdy, Rana Hanisch, Benjamin Harik, Nada Jantausch, Barbara A Koay, Adeline Campos, Joseph M Delaney, Meghan Simpson, Joelle Cora-Bramble, Denice Wessel, David |
author_sort | DeBiasi, Roberta L |
collection | PubMed |
description | BACKGROUND: Children and young adults were initially reported as largely spared from severe complications of SARS-CoV-2 infection, but the impact to this population has been significant. METHODS: This observational retrospective cohort study includes 420 symptomatic children and young adults with lab confirmed SARS-CoV-2 infection treated between March 15 and June 16, 2020 at Children’s National Hospital in Washington DC. We identified and compared cohorts of non-hospitalized (N=324) and hospitalized (N=96) patients, including non-critically ill (N=64) and critically ill hospitalized (N=32) patients. Clinical and demographic data were extracted from medical records RESULTS: Of 420 SARS-CoV-2-infected symptomatic patients, 23% required hospitalization, of which 67% were non-critically ill and 33% were critically ill. All age groups were represented in the symptomatic cohort, with a median age of 8.6 years. Patients > 15 years of age represented 44% of critical care admissions. Males and females were equally represented in all cohorts. Underlying medical conditions were present in 36%, but more common in hospitalized (59 %) and critically ill (66 %) patients. The most frequent underlying diagnosis overall was asthma (16 %), but also included neurologic (6 %), diabetes (3 %), obesity (3 %), cardiac (3 %), hematologic (3 %) and oncologic (1 %) conditions. The majority (66 %) of SARS-CoV-2 infected patients presented with respiratory symptoms with or without fever. Other symptoms were also present, including diarrhea/vomiting (21 %), myalgia (11 %), chest pain (8 %) and loss of sense of smell or taste (7%). Hospitalized patients required varying levels of respiratory support, including mechanical ventilation, BiPAP, RAM cannula and HFNC. Additional presentations included diabetic hyperglycemia, sickle cell vaso-occlusive crisis, vascular complications, and multisystem inflammation. Treatment included remdesivir, convalescent plasma, tocilizumab and other therapies. CONCLUSION: Although children/young adults have been less affected than elderly adults, the impact of SARS-CoV2 on this population has been significant in Washington DC and informs other regions anticipating their surge. DISCLOSURES: Andrea Hahn, MD, MS, Johnson and Johnson (Consultant) |
format | Online Article Text |
id | pubmed-7776997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77769972021-01-07 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region DeBiasi, Roberta L Song, Xiaoyan Ansusinha, Emily Smith, Karen L Bell, Michael Pershad, Jay Hahn, Andrea Hamdy, Rana Hanisch, Benjamin Harik, Nada Jantausch, Barbara A Koay, Adeline Campos, Joseph M Delaney, Meghan Simpson, Joelle Cora-Bramble, Denice Wessel, David Open Forum Infect Dis Poster Abstracts BACKGROUND: Children and young adults were initially reported as largely spared from severe complications of SARS-CoV-2 infection, but the impact to this population has been significant. METHODS: This observational retrospective cohort study includes 420 symptomatic children and young adults with lab confirmed SARS-CoV-2 infection treated between March 15 and June 16, 2020 at Children’s National Hospital in Washington DC. We identified and compared cohorts of non-hospitalized (N=324) and hospitalized (N=96) patients, including non-critically ill (N=64) and critically ill hospitalized (N=32) patients. Clinical and demographic data were extracted from medical records RESULTS: Of 420 SARS-CoV-2-infected symptomatic patients, 23% required hospitalization, of which 67% were non-critically ill and 33% were critically ill. All age groups were represented in the symptomatic cohort, with a median age of 8.6 years. Patients > 15 years of age represented 44% of critical care admissions. Males and females were equally represented in all cohorts. Underlying medical conditions were present in 36%, but more common in hospitalized (59 %) and critically ill (66 %) patients. The most frequent underlying diagnosis overall was asthma (16 %), but also included neurologic (6 %), diabetes (3 %), obesity (3 %), cardiac (3 %), hematologic (3 %) and oncologic (1 %) conditions. The majority (66 %) of SARS-CoV-2 infected patients presented with respiratory symptoms with or without fever. Other symptoms were also present, including diarrhea/vomiting (21 %), myalgia (11 %), chest pain (8 %) and loss of sense of smell or taste (7%). Hospitalized patients required varying levels of respiratory support, including mechanical ventilation, BiPAP, RAM cannula and HFNC. Additional presentations included diabetic hyperglycemia, sickle cell vaso-occlusive crisis, vascular complications, and multisystem inflammation. Treatment included remdesivir, convalescent plasma, tocilizumab and other therapies. CONCLUSION: Although children/young adults have been less affected than elderly adults, the impact of SARS-CoV2 on this population has been significant in Washington DC and informs other regions anticipating their surge. DISCLOSURES: Andrea Hahn, MD, MS, Johnson and Johnson (Consultant) Oxford University Press 2020-12-31 /pmc/articles/PMC7776997/ http://dx.doi.org/10.1093/ofid/ofaa439.738 Text en © The Author 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Poster Abstracts DeBiasi, Roberta L Song, Xiaoyan Ansusinha, Emily Smith, Karen L Bell, Michael Pershad, Jay Hahn, Andrea Hamdy, Rana Hanisch, Benjamin Harik, Nada Jantausch, Barbara A Koay, Adeline Campos, Joseph M Delaney, Meghan Simpson, Joelle Cora-Bramble, Denice Wessel, David 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region |
title | 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region |
title_full | 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region |
title_fullStr | 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region |
title_full_unstemmed | 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region |
title_short | 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region |
title_sort | 544. severe covid-19 in children and young adults in the washington dc metropolitan region |
topic | Poster Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776997/ http://dx.doi.org/10.1093/ofid/ofaa439.738 |
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