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544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region

BACKGROUND: Children and young adults were initially reported as largely spared from severe complications of SARS-CoV-2 infection, but the impact to this population has been significant. METHODS: This observational retrospective cohort study includes 420 symptomatic children and young adults with la...

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Autores principales: DeBiasi, Roberta L, Song, Xiaoyan, Ansusinha, Emily, Smith, Karen L, Bell, Michael, Pershad, Jay, Hahn, Andrea, Hamdy, Rana, Hanisch, Benjamin, Harik, Nada, Jantausch, Barbara A, Koay, Adeline, Campos, Joseph M, Delaney, Meghan, Simpson, Joelle, Cora-Bramble, Denice, Wessel, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776997/
http://dx.doi.org/10.1093/ofid/ofaa439.738
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author DeBiasi, Roberta L
Song, Xiaoyan
Ansusinha, Emily
Smith, Karen L
Bell, Michael
Pershad, Jay
Hahn, Andrea
Hamdy, Rana
Hanisch, Benjamin
Harik, Nada
Jantausch, Barbara A
Koay, Adeline
Campos, Joseph M
Delaney, Meghan
Simpson, Joelle
Cora-Bramble, Denice
Wessel, David
author_facet DeBiasi, Roberta L
Song, Xiaoyan
Ansusinha, Emily
Smith, Karen L
Bell, Michael
Pershad, Jay
Hahn, Andrea
Hamdy, Rana
Hanisch, Benjamin
Harik, Nada
Jantausch, Barbara A
Koay, Adeline
Campos, Joseph M
Delaney, Meghan
Simpson, Joelle
Cora-Bramble, Denice
Wessel, David
author_sort DeBiasi, Roberta L
collection PubMed
description BACKGROUND: Children and young adults were initially reported as largely spared from severe complications of SARS-CoV-2 infection, but the impact to this population has been significant. METHODS: This observational retrospective cohort study includes 420 symptomatic children and young adults with lab confirmed SARS-CoV-2 infection treated between March 15 and June 16, 2020 at Children’s National Hospital in Washington DC. We identified and compared cohorts of non-hospitalized (N=324) and hospitalized (N=96) patients, including non-critically ill (N=64) and critically ill hospitalized (N=32) patients. Clinical and demographic data were extracted from medical records RESULTS: Of 420 SARS-CoV-2-infected symptomatic patients, 23% required hospitalization, of which 67% were non-critically ill and 33% were critically ill. All age groups were represented in the symptomatic cohort, with a median age of 8.6 years. Patients > 15 years of age represented 44% of critical care admissions. Males and females were equally represented in all cohorts. Underlying medical conditions were present in 36%, but more common in hospitalized (59 %) and critically ill (66 %) patients. The most frequent underlying diagnosis overall was asthma (16 %), but also included neurologic (6 %), diabetes (3 %), obesity (3 %), cardiac (3 %), hematologic (3 %) and oncologic (1 %) conditions. The majority (66 %) of SARS-CoV-2 infected patients presented with respiratory symptoms with or without fever. Other symptoms were also present, including diarrhea/vomiting (21 %), myalgia (11 %), chest pain (8 %) and loss of sense of smell or taste (7%). Hospitalized patients required varying levels of respiratory support, including mechanical ventilation, BiPAP, RAM cannula and HFNC. Additional presentations included diabetic hyperglycemia, sickle cell vaso-occlusive crisis, vascular complications, and multisystem inflammation. Treatment included remdesivir, convalescent plasma, tocilizumab and other therapies. CONCLUSION: Although children/young adults have been less affected than elderly adults, the impact of SARS-CoV2 on this population has been significant in Washington DC and informs other regions anticipating their surge. DISCLOSURES: Andrea Hahn, MD, MS, Johnson and Johnson (Consultant)
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spelling pubmed-77769972021-01-07 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region DeBiasi, Roberta L Song, Xiaoyan Ansusinha, Emily Smith, Karen L Bell, Michael Pershad, Jay Hahn, Andrea Hamdy, Rana Hanisch, Benjamin Harik, Nada Jantausch, Barbara A Koay, Adeline Campos, Joseph M Delaney, Meghan Simpson, Joelle Cora-Bramble, Denice Wessel, David Open Forum Infect Dis Poster Abstracts BACKGROUND: Children and young adults were initially reported as largely spared from severe complications of SARS-CoV-2 infection, but the impact to this population has been significant. METHODS: This observational retrospective cohort study includes 420 symptomatic children and young adults with lab confirmed SARS-CoV-2 infection treated between March 15 and June 16, 2020 at Children’s National Hospital in Washington DC. We identified and compared cohorts of non-hospitalized (N=324) and hospitalized (N=96) patients, including non-critically ill (N=64) and critically ill hospitalized (N=32) patients. Clinical and demographic data were extracted from medical records RESULTS: Of 420 SARS-CoV-2-infected symptomatic patients, 23% required hospitalization, of which 67% were non-critically ill and 33% were critically ill. All age groups were represented in the symptomatic cohort, with a median age of 8.6 years. Patients > 15 years of age represented 44% of critical care admissions. Males and females were equally represented in all cohorts. Underlying medical conditions were present in 36%, but more common in hospitalized (59 %) and critically ill (66 %) patients. The most frequent underlying diagnosis overall was asthma (16 %), but also included neurologic (6 %), diabetes (3 %), obesity (3 %), cardiac (3 %), hematologic (3 %) and oncologic (1 %) conditions. The majority (66 %) of SARS-CoV-2 infected patients presented with respiratory symptoms with or without fever. Other symptoms were also present, including diarrhea/vomiting (21 %), myalgia (11 %), chest pain (8 %) and loss of sense of smell or taste (7%). Hospitalized patients required varying levels of respiratory support, including mechanical ventilation, BiPAP, RAM cannula and HFNC. Additional presentations included diabetic hyperglycemia, sickle cell vaso-occlusive crisis, vascular complications, and multisystem inflammation. Treatment included remdesivir, convalescent plasma, tocilizumab and other therapies. CONCLUSION: Although children/young adults have been less affected than elderly adults, the impact of SARS-CoV2 on this population has been significant in Washington DC and informs other regions anticipating their surge. DISCLOSURES: Andrea Hahn, MD, MS, Johnson and Johnson (Consultant) Oxford University Press 2020-12-31 /pmc/articles/PMC7776997/ http://dx.doi.org/10.1093/ofid/ofaa439.738 Text en © The Author 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Abstracts
DeBiasi, Roberta L
Song, Xiaoyan
Ansusinha, Emily
Smith, Karen L
Bell, Michael
Pershad, Jay
Hahn, Andrea
Hamdy, Rana
Hanisch, Benjamin
Harik, Nada
Jantausch, Barbara A
Koay, Adeline
Campos, Joseph M
Delaney, Meghan
Simpson, Joelle
Cora-Bramble, Denice
Wessel, David
544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region
title 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region
title_full 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region
title_fullStr 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region
title_full_unstemmed 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region
title_short 544. Severe COVID-19 in Children and Young Adults in the Washington DC Metropolitan Region
title_sort 544. severe covid-19 in children and young adults in the washington dc metropolitan region
topic Poster Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776997/
http://dx.doi.org/10.1093/ofid/ofaa439.738
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