Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons

Axon injury is a hallmark of many neurodegenerative diseases, often resulting in neuronal cell death and functional impairment. Dual leucine zipper kinase (DLK) has emerged as a key mediator of this process. However, while DLK inhibition is robustly protective in a wide range of neurodegenerative di...

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Detalles Bibliográficos
Autores principales: Patel, Amit K., Broyer, Risa M., Lee, Cassidy D., Lu, Tianlun, Louie, Mikaela J., La Torre, Anna, Al-Ali, Hassan, Vu, Mai T., Mitchell, Katherine L., Wahlin, Karl J., Berlinicke, Cynthia A., Jaskula-Ranga, Vinod, Hu, Yang, Duan, Xin, Vilar, Santiago, Bixby, John L., Weinreb, Robert N., Lemmon, Vance P., Zack, Donald J., Welsbie, Derek S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777023/
https://www.ncbi.nlm.nih.gov/pubmed/33318207
http://dx.doi.org/10.1073/pnas.2004683117

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