197. Dengue Virus Infection Among Renal Transplant Recipients in Singapore: A 15-year Single Center Retrospective Review

BACKGROUND: Dengue is a mosquito-borne viral infection endemic in Singapore. Its clinical course in the immunocompetent host is well characterised but its impact in renal transplantation is not well described. We aim to characterise the clinical presentation and outcomes of dengue virus infection in renal transplant recipients treated at a tertiary center in Singapore. METHODS: We conducted a 15 year retrospective review of dengue in renal transplant patients treated at Singapore General Hospital between January 2005 to October 2019. The diagnosis of dengue was made if there were a compatible clinical syndrome and a positive dengue diagnostic assay, either Dengue NS1 antigen, IgM or PCR. RESULTS: Thirty-two renal transplant patients were diagnosed with dengue, 18 (56.3%) were deceased donor recipients. The median age at time of diagnosis was 53 [IQR 42,61] years; 16 (50%) were males. The median time to diagnosis of dengue was 95.5 [IQR 15.0,95.5] months from transplant; and the median duration of clinical illness was 7 [IQR 5,7] days. The most common clinical symptoms were fever (84.4%), myalgia (40.6%), gastrointestinal symptoms (37.5%) and headache (25.0%). Based on the WHO 2009 dengue classification, 20 (62.5%) had dengue without warning signs, 9 (28.1%) had dengue with warning signs, and 3 (9.4%) had severe dengue; 19 (59.3%) had graft dysfunction and 1 (3.1%) required dialysis. Of the patients who had graft dysfunction, 18 (94.7%) had recovery of graft function at time of dengue resolution. Dengue mortality rate was 3.1%. There were 2 possible cases of donor derived dengue infections, occurring within 2 weeks of deceased donor transplantation. CONCLUSION: Dengue in renal transplant is usually community acquired; donor derived infections are uncommon. The clinical presentation of dengue is similar to the immunocompetent host, however graft dysfunction is common and fluid management in this population is important. Severe dengue is less common. DISCLOSURES: All Authors: No reported disclosures