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493. Clinical and Epidemiological Features of Healthcare Workers Detected with Coronavirus Disease

BACKGROUND: Data early in the SARS-CoV-2 pandemic suggested frontline healthcare workers (HCW) may account for 10–20% of all infections. CDC estimated 600,000 infections in HCWs. Symptom screening is a strategy to prevent healthcare-associated transmission. This method may not identify asymptomatic...

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Autores principales: Campbell, Melissa, Datta, Rupak, Wyllie, Anne, Casanovas-Massana, Arnau, Handoko, Ryan, Sewanan, Lorenzo, Ko, Albert I, Martinello, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777234/
http://dx.doi.org/10.1093/ofid/ofaa439.686
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author Campbell, Melissa
Datta, Rupak
Wyllie, Anne
Casanovas-Massana, Arnau
Handoko, Ryan
Sewanan, Lorenzo
Ko, Albert I
Martinello, Richard A
author_facet Campbell, Melissa
Datta, Rupak
Wyllie, Anne
Casanovas-Massana, Arnau
Handoko, Ryan
Sewanan, Lorenzo
Ko, Albert I
Martinello, Richard A
author_sort Campbell, Melissa
collection PubMed
description BACKGROUND: Data early in the SARS-CoV-2 pandemic suggested frontline healthcare workers (HCW) may account for 10–20% of all infections. CDC estimated 600,000 infections in HCWs. Symptom screening is a strategy to prevent healthcare-associated transmission. This method may not identify asymptomatic or pre-symptomatic carriers. METHODS: We conducted a prospective cohort study in asymptomatic or minimally symptomatic healthcare workers in a 1541-bed academic medical center. Although recruitment began in designated COVID-19 units, we expanded to all HCWs providing care to hospitalized patients during the pandemic. Data was gathered on demographics, work area in the hospital and daily questionnaires were sent listing symptoms of SARS-CoV-2. Protocol included twice weekly self-collected nasopharyngeal swab and saliva for SARS-CoV-2 N1 and N2.Those with positive PCR result, underwent telephone survey to assess symptomatology and severity of illness. RESULTS: A total 525 HCWs began the study protocol and 16 were identified as PCR positive. Samples included concordant saliva and NP samples on 9 (56%), exclusively NP samples on 5 (31%) and 2 (12%) HCWs were positive by saliva PCR only. Majority were female, and all were nursing staff; with 19% reported not working in a designated COVID-19 unit. During the course of this active surveillance, universal masking was mandated in the institution. Rhinorrhea and headache were reported by 6 (38%), 5 (31%) reported cough and 3 (19%) developed myalgia. Changes in smell and taste preceded the positive PCR test in 2 (12%). One HCW reported developing a fever with acute illness. All were notified about their PCR positive status by institution’s occupational health department and self-isolated to monitor for symptoms. CONCLUSION: The spectrum of disease in this HCW cohort is similar to mild disease in the community. Due to high incidence of asymptomatic or mildly symptomatic HCWs, active surveillance with routine testing proves be beneficial to prevent hospital transmission of SARS-CoV-2. Universal masking significantly decreased the HCW positive rate in our study, underscoring the need for universal efforts to mitigate healthcare-associated transmission with self-monitoring, face mask use, and other infection prevention behaviors like hand hygiene. DISCLOSURES: All Authors: No reported disclosures
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spelling pubmed-77772342021-01-07 493. Clinical and Epidemiological Features of Healthcare Workers Detected with Coronavirus Disease Campbell, Melissa Datta, Rupak Wyllie, Anne Casanovas-Massana, Arnau Handoko, Ryan Sewanan, Lorenzo Ko, Albert I Martinello, Richard A Open Forum Infect Dis Poster Abstracts BACKGROUND: Data early in the SARS-CoV-2 pandemic suggested frontline healthcare workers (HCW) may account for 10–20% of all infections. CDC estimated 600,000 infections in HCWs. Symptom screening is a strategy to prevent healthcare-associated transmission. This method may not identify asymptomatic or pre-symptomatic carriers. METHODS: We conducted a prospective cohort study in asymptomatic or minimally symptomatic healthcare workers in a 1541-bed academic medical center. Although recruitment began in designated COVID-19 units, we expanded to all HCWs providing care to hospitalized patients during the pandemic. Data was gathered on demographics, work area in the hospital and daily questionnaires were sent listing symptoms of SARS-CoV-2. Protocol included twice weekly self-collected nasopharyngeal swab and saliva for SARS-CoV-2 N1 and N2.Those with positive PCR result, underwent telephone survey to assess symptomatology and severity of illness. RESULTS: A total 525 HCWs began the study protocol and 16 were identified as PCR positive. Samples included concordant saliva and NP samples on 9 (56%), exclusively NP samples on 5 (31%) and 2 (12%) HCWs were positive by saliva PCR only. Majority were female, and all were nursing staff; with 19% reported not working in a designated COVID-19 unit. During the course of this active surveillance, universal masking was mandated in the institution. Rhinorrhea and headache were reported by 6 (38%), 5 (31%) reported cough and 3 (19%) developed myalgia. Changes in smell and taste preceded the positive PCR test in 2 (12%). One HCW reported developing a fever with acute illness. All were notified about their PCR positive status by institution’s occupational health department and self-isolated to monitor for symptoms. CONCLUSION: The spectrum of disease in this HCW cohort is similar to mild disease in the community. Due to high incidence of asymptomatic or mildly symptomatic HCWs, active surveillance with routine testing proves be beneficial to prevent hospital transmission of SARS-CoV-2. Universal masking significantly decreased the HCW positive rate in our study, underscoring the need for universal efforts to mitigate healthcare-associated transmission with self-monitoring, face mask use, and other infection prevention behaviors like hand hygiene. DISCLOSURES: All Authors: No reported disclosures Oxford University Press 2020-12-31 /pmc/articles/PMC7777234/ http://dx.doi.org/10.1093/ofid/ofaa439.686 Text en © The Author 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Abstracts
Campbell, Melissa
Datta, Rupak
Wyllie, Anne
Casanovas-Massana, Arnau
Handoko, Ryan
Sewanan, Lorenzo
Ko, Albert I
Martinello, Richard A
493. Clinical and Epidemiological Features of Healthcare Workers Detected with Coronavirus Disease
title 493. Clinical and Epidemiological Features of Healthcare Workers Detected with Coronavirus Disease
title_full 493. Clinical and Epidemiological Features of Healthcare Workers Detected with Coronavirus Disease
title_fullStr 493. Clinical and Epidemiological Features of Healthcare Workers Detected with Coronavirus Disease
title_full_unstemmed 493. Clinical and Epidemiological Features of Healthcare Workers Detected with Coronavirus Disease
title_short 493. Clinical and Epidemiological Features of Healthcare Workers Detected with Coronavirus Disease
title_sort 493. clinical and epidemiological features of healthcare workers detected with coronavirus disease
topic Poster Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777234/
http://dx.doi.org/10.1093/ofid/ofaa439.686
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