A general fragment-based approach to identify and optimize bioactive ligands targeting RNA

RNAs have important functions that are dictated by their structure. Indeed, small molecules that interact with RNA structures can perturb function, serving as chemical probes and lead medicines. Here we describe the development of a fragment-based approach to discover and optimize bioactive small mo...

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Detalles Bibliográficos
Autores principales: Suresh, Blessy M., Li, Weichao, Zhang, Peiyuan, Wang, Kye Won, Yildirim, Ilyas, Parker, Christopher G., Disney, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777249/
https://www.ncbi.nlm.nih.gov/pubmed/33318191
http://dx.doi.org/10.1073/pnas.2012217117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777249/
https://www.ncbi.nlm.nih.gov/pubmed/33318191
http://dx.doi.org/10.1073/pnas.2012217117

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