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1634. Meningeal Tuberculosis: Experience of a Series of Cases from Cali, Colombia, 2008 - 2018

BACKGROUND: Meningeal tuberculosis (MTB) is the most lethal and disabling form of Mycobacterium Tuberculosis infection. In Colombia, it represents the second most frequent extrapulmonary location. Co-infection with the Human Immunodeficiency Virus (HIV) is one of the factors that most impacts their...

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Autores principales: Tello-Cajiao, Maria E, Romero-Rosas, Nelson, Vargas-Potes, Carlos, Valencia-Sabogal, jaime, García-Goez, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777316/
http://dx.doi.org/10.1093/ofid/ofaa439.1814
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author Tello-Cajiao, Maria E
Romero-Rosas, Nelson
Vargas-Potes, Carlos
Valencia-Sabogal, jaime
García-Goez, Jose
author_facet Tello-Cajiao, Maria E
Romero-Rosas, Nelson
Vargas-Potes, Carlos
Valencia-Sabogal, jaime
García-Goez, Jose
author_sort Tello-Cajiao, Maria E
collection PubMed
description BACKGROUND: Meningeal tuberculosis (MTB) is the most lethal and disabling form of Mycobacterium Tuberculosis infection. In Colombia, it represents the second most frequent extrapulmonary location. Co-infection with the Human Immunodeficiency Virus (HIV) is one of the factors that most impacts their clinical results. Therefore, in this article we present the experience of 10 years of managing patients with MTB, with and without HIV coinfection. METHODS: A retrospective observational study was conducted between January 2008 and December 2018, with clinical information from patients diagnosed with MTB at Teaching Hospital Fundación Valle del Lili. Using absolute and relative frequency tables, sociodemographic, clinical characteristics and treatment outcomes were described, according to HIV infection status. P values < 0.05 were taken as significant and 95% confidence intervals were used for comparison of proportions. RESULTS: 61 patients with MTB diagnosed were enrolled. They represented 6.43% of all TB locations in the institutional registry. HIV coinfection was found in 26.2% of cases (n=16). Most of patients were men (65.6%), from urban areas (78.7%), and a median age of 39 years. Acute and subacute evolution of the infection was observed in half of the patients (50.8%). Also 85% presented some degree of neurological impairment. Bacteriological demonstration was achieved in 60.6% of all cases. 88% received drugs for sensitive TB, for a median of 9.5 months, and 52.5% received concomitant steroids drugs. Of the 36 subjects with information about their outcome, 42.6% were successful at treatment, 1 failed in the non-HIV group and 9 died (1 with HIV). 77% of all deaths were associated with TB. CONCLUSION: MTB generates a significant burden disease. The characteristics of its insidious clinical presentation and the difficulty in achieving bacteriological demonstration in all patients make its timely diagnostic and therapeutic approach challenging. DISCLOSURES: All Authors: No reported disclosures
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spelling pubmed-77773162021-01-07 1634. Meningeal Tuberculosis: Experience of a Series of Cases from Cali, Colombia, 2008 - 2018 Tello-Cajiao, Maria E Romero-Rosas, Nelson Vargas-Potes, Carlos Valencia-Sabogal, jaime García-Goez, Jose Open Forum Infect Dis Poster Abstracts BACKGROUND: Meningeal tuberculosis (MTB) is the most lethal and disabling form of Mycobacterium Tuberculosis infection. In Colombia, it represents the second most frequent extrapulmonary location. Co-infection with the Human Immunodeficiency Virus (HIV) is one of the factors that most impacts their clinical results. Therefore, in this article we present the experience of 10 years of managing patients with MTB, with and without HIV coinfection. METHODS: A retrospective observational study was conducted between January 2008 and December 2018, with clinical information from patients diagnosed with MTB at Teaching Hospital Fundación Valle del Lili. Using absolute and relative frequency tables, sociodemographic, clinical characteristics and treatment outcomes were described, according to HIV infection status. P values < 0.05 were taken as significant and 95% confidence intervals were used for comparison of proportions. RESULTS: 61 patients with MTB diagnosed were enrolled. They represented 6.43% of all TB locations in the institutional registry. HIV coinfection was found in 26.2% of cases (n=16). Most of patients were men (65.6%), from urban areas (78.7%), and a median age of 39 years. Acute and subacute evolution of the infection was observed in half of the patients (50.8%). Also 85% presented some degree of neurological impairment. Bacteriological demonstration was achieved in 60.6% of all cases. 88% received drugs for sensitive TB, for a median of 9.5 months, and 52.5% received concomitant steroids drugs. Of the 36 subjects with information about their outcome, 42.6% were successful at treatment, 1 failed in the non-HIV group and 9 died (1 with HIV). 77% of all deaths were associated with TB. CONCLUSION: MTB generates a significant burden disease. The characteristics of its insidious clinical presentation and the difficulty in achieving bacteriological demonstration in all patients make its timely diagnostic and therapeutic approach challenging. DISCLOSURES: All Authors: No reported disclosures Oxford University Press 2020-12-31 /pmc/articles/PMC7777316/ http://dx.doi.org/10.1093/ofid/ofaa439.1814 Text en © The Author 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Abstracts
Tello-Cajiao, Maria E
Romero-Rosas, Nelson
Vargas-Potes, Carlos
Valencia-Sabogal, jaime
García-Goez, Jose
1634. Meningeal Tuberculosis: Experience of a Series of Cases from Cali, Colombia, 2008 - 2018
title 1634. Meningeal Tuberculosis: Experience of a Series of Cases from Cali, Colombia, 2008 - 2018
title_full 1634. Meningeal Tuberculosis: Experience of a Series of Cases from Cali, Colombia, 2008 - 2018
title_fullStr 1634. Meningeal Tuberculosis: Experience of a Series of Cases from Cali, Colombia, 2008 - 2018
title_full_unstemmed 1634. Meningeal Tuberculosis: Experience of a Series of Cases from Cali, Colombia, 2008 - 2018
title_short 1634. Meningeal Tuberculosis: Experience of a Series of Cases from Cali, Colombia, 2008 - 2018
title_sort 1634. meningeal tuberculosis: experience of a series of cases from cali, colombia, 2008 - 2018
topic Poster Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777316/
http://dx.doi.org/10.1093/ofid/ofaa439.1814
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